| AimSimple renal cysts may be an early marker of renal disease.We investigated whether simple cysts in donor kidney are associated with the decline of allograft function in living donor kidney transplantation.MethodsWe retrospectively reviewed donors and recipients records of 716 living donor kidney transplants performed between April 2007 and April 2015 in our hospital.91 donors with renal cysts and 64 recipients with cysts in donor kidney were noted.We compared these 64 cases to 128 no cyst-bearing controls matched for the donor gender,recipient gender,donor baseline serum creatinine,donor/recipient body surface area(BSA)ratio,donor age,recipient age,and the date of kidney transplantation in turn.Then analysed the prognosis of grafts between the two groups.ResultsThe presence of cysts was interrelated with age,gender and renal function independently in donors.Pathological findings of time-zero biopsy revealed donor kidney harboring cysts existed more glomerular sclerosis compared with no cyst-bearing controls(P=0.040).The estimating glomerular filtration rate levels of recipients were 80.82± 26.61 vs.88.21 ± 23.12,66.95±17.42 vs.72.15±16.42,60.92±22.17 vs.68.72± 14.43 ml/(in·1.73m2)in cyst-bearing and no cyst-bearing group on day 7,month 6,year 5 respectively after surgery(P<0.05).The mean serum creatinine were 112.14±48.32 vs.98.75±29.71,126.28±42.32 vs.115.05±26.35 ?mol/l on the seventh day and a half year after transplant(P<0.05).The two groups did not significantly differ in terms of five year graft and patient survival rate.ConclusionsSimple cysts in donor kidney can influence the early and long-term allograft function.In living donor transplantation,kidney presenting cysts should be considered carefully at the time of donor selection. |
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