The Study On The Mean Platelet Volume Level In Patients With Subcortical Ischemic Vascular Disease

Background and Objective With the accelerating of the aging society and high-incidence of cerebrovascular diseases,The number of patients with subcortical ischemic vascular disease(SIVD)are increasing progressively.Though the pathogenesis of SIVD is concealed and SIVD is always easily neglected by the patients,family members and medical staffs,the potential risk of developing into stroke or dementia can negatively affect patients' living quality and bring about heavy family and social burdens.In recent years,the relation between platelet function and various diseases have been paid much attention to by the academia,in particular,abnormal MPV as a new risk factor for many diseases.Previous studies have shown that MPV alteration was closely related to stroke,Alzheimer's disease,coronary heart disease or other disorders.However,few researches on relation between SIVD and MPV were reported.This study was aimed to discuss the MPV level changes in SIVD patients and its clinical implications by MPV detection in SIVD patients.Materials and methods A total of 340 patients with SIVD(SIVD group)and 160 health physical examination individuals(the control group)were enrolled into this study.According to magnetic resonance imaging(MRI)appearances,the SIVD group was further devided into lacunar infarction(LI)(n=124)and leukoaraiosis(LA)(n=216)subtypes.The severity of LA was further graded according to the Fazekas scale.The hematology analyzers was applied to examine the level of MPV in all subjects.The MPV levels between the subtypes of SIVD and the controls were compared and the analysis was made of the relationship between MPV and the severity of LA.Results SIVD group had more elder subjects and higher hypertension proportion than control group,and the differences were statistically significant(P<0.01);MPV and PDW level in SIVD group were significantly higher than that in control group,platelet count level in SIVD group was noticeably lower than that of control group,and the differences were significant(P<0.01).Moreover,the MPV and PDW level in LA subgroup were significantly higher than that in the LI subgroup(P<0.01).Meanwhile,As the severity of LA aggravated,MPV level increased significantly(11.06±0.76 fl ?12.13±0.88fl?12.64±1.02 fl,P<0.01).The level of MPV was positive with the severity of LA(rs=0.596,P<0.01).When independent variables,such as age,gender,hypertension,diabetes,coronary heart disease,smoking and MPV level were fixed for multiple logistic regression analysis with SIVD as dependent variable,MPV level was still certified as the main risk factor for SIVD development.(OR=3.461,95%CI:2.653-4.515,P<0.01).Conclusions MPV level in SIVD patients was significantly higher than that of health population,indicating elevated MPV level was a potential independent risk factor for SIVD and closely related to the severity of LA.Multiple mechanisms were involved in SIVD development via elevated MPV level,while the formation of large platelets still remained unclear,which needed to be clarified by more fundamental and clinical researches.Continuously monitoring of MPV level in patients and actively applying anti-platelet drugs were suggested in SIVD clinical practices to improve the prognosis.