The Meta-analysis Of The Relationship Between The PARP Expression And Clinicopathological Characteristics And Prognosis In Breast Cancer

Objective:To systematically evaluate the relationship between the poly adenosine diphosphate-ribose polymerase(PARP)expression level and clinicopathological characteristics and the survival outcome in breast cancer by meta-analysis.Methods:Eligible studies were retrieved from the Pub Med,Web of Science,Embase,Cochrane Library,CNKI,CBM and Wan fang databases through December 20,2016.Studies investigating PARP expression as well as reporting survival data in breast cancer were included.Two independent reviewers carried out all literature searches.The pooled hazard ratio(HR)with 95% confidence interval(95% CI)was applied to assess the association between PARP expression and disease-free survival and overall survival in breast cancer.Moreover,the pooled relative risk(RR)with 95% CI was applied to assess the association between PARP expression and the clinicopathological features in breast cancer,such as nuclear grade,triple-negative breast cancer,age,tumor size,lymph node metastasis,BRCA1 status,ER status,PR status,HER2 status,Ki67 status,and pCR.Results:A total of 3506 patients from eight eligible studies were included.The meta analysis showed that higher PARP expression indicated a worse clinical outcome in early stage breast cancer,with a HR of 3.08(95% CI,1.14-8.29;P=0.03)for disease-free survival and a HR of 1.82(95% CI,1.20-2.76;P=0.005)for overall survival.Moreover,increased PARP expression was significantly associated with higher nuclear grade(RR=1.34;95% CI,1.10-1.63;P=0.004)in breast cancer.A similar correlation was detected in triple-negative breast cancer(TNBC;RR=1.37;95% CI,1.06-1.77;P=0.02).However,no significant correlation was revealed between the PARP expression level and other clinicopathological parameters,including age,tumor size,lymph node metastasis,BRCA1 status,ER status,PR status,HER2 status,Ki67 status,and pCR.Conclusion:1.High PARP expression was correlated with worse prognosis in early stage breast cancer.2.High PARP expression was associated with higher nuclear grade and TNBC.3.There was no significant correlation was revealed between the PARP expression level and other clinicopathological parameters,including age,tumor size,lymph node metastasis,BRCA1 status,ER status,PR status,HER2 status,Ki67 status,and pCR.