The Clinical Research Of Vascular Cognitive Impairment Not Dementia After Lacunar Infarction

Objective:To explore the clinical characters and influencing facters of vascular cognitive impairment not dementia(VCIND)after Lacunar infarction(LI);Mathods: According to the diagnostic criteria of LI,A total of 120 Lacunar infarction patients from the First Affiliated Hospital of Xinjiang Medical University from December 2015 to June 2016 were recruited to be scored in reference to related cognitive neural scale;76 patients with VCIND and 44 patients in normal cognitive state were screened out into VCIND group and control group(NC group)respectively.Age,genda,years of education,smoking history,history of hypertension,history of diabetes millus,history of hyperhomocysteinemia,history of transient ischemic attacks,the grade of intracranial and carotid artery stenosis,score of white matter lesions and the score of the cognitive function of patients in the two groups were compared,and the relationship between the above factors and VCIND after LI was analyzed;Results: There were significant differences of two groups in age,gender,educated years,smoking history,hypertension,the score of mini-mental state examination(MMSE)and Montreal cognitive assedssment(MoCA)of patients in the two groups(P<0.05).The grading of intracranial and carotid artery stenosis and score of deep white matter lesion in NC groug were better than those in VCIND group(P<0.05)The vascular stenosis of 3rd and 4th grade,and deep white matter lesion of 3 scores were the risk factors of VCIND after LI,and years of education was the protective factor of VCIND after LI(P>0.05).Conclusions: The cognitive impairment of patients with VCIND after LI is manifested in visual space,executive function,naming,attention,abstraction and ability of delayed recall,and vascular stenosis degree of 3rd and 4th grade in head and neck,and deep white matter lesion are associated with cognitive impairment of patients with VICND after LI.