Study On The Association Between Urinary Angiotensinogen And Chronic Kidney Disease

Objective: To analyze the correlation between angiotensinogen(AGT)and chronic renal disease(CKD)patients,and to explore the significance of urinary AGT in the diagnosis of CKD.Methods: Extraction of CKD and non CKD samples from the CKD resource repository in a cross-sectional survey,CKD was divided into 3 groups according to glomerular filtration rate(eGFR unit: ml/min/1.73m): normal group(eGFR?90),critical group(60?eGFR<90),decreased(30?eGFR<60).CKD group and non CKD group systolic blood pressure in the 80-220 mmHg interval,and according to every 20 mm Hg to group.UrineAGT was detected by enzyme-linked immunosorbent assay.One-way-ANOVA analysis group differences,multivariate analysis using multiple linear regression analysis.Results: A total of 95 CKD patients and 413 non CKD controls were enrolled in this study.CKD in group AGT was significantly higher than that in non CKD group(243.97±47.86 vs 158.43±25.14 t=16.892 P<0.01);With the decrease of glomerular filtration rate,urine AGT increased,the urine AGT of the normal group,the critical group and the descending group were 213.63±34.47ng/L,251.39±17.17ng/L,314.97±27.58ng/L,there was significant difference between the groups(F=81.103 P<0.01).At the same level of blood pressure,urine AGT in CKD group were significantly higher than those in non CKD group,the difference was statistically significant(P<0.01);In the CKD group,with the increase of systolic blood pressure,the urine AGT level was further increased,and the systolic blood pressure was in the interval of 140-160 mmHg and 160-180 mmHg,the difference was statistically significant(P<0.01).Multiple linear regression analysis showed that urinary AGT was positively correlated with ACR and Scr,and negatively correlated with eGFR.Conclusions: Urinary AGT was higher than that of non CKD in patients with chronic kidney disease;With the increase in systolic blood pressure,urinary AGT levels increased in patients with chronic kidney disease;Urinary AGT was positivelycorrelated with ACR and Scr,and negatively correlated with eGFR,suggesting that urinary angiotensinogen could be used as a biomarker for early prediction and progression of chronic kidney disease.