The Research Advances Of Ascite Laboratory Examination In The Differential Diagnosis Of Benign And Malignant Ascite

Background:Ascites is a common clinical signs.The diagnosis,treatment and long-term prognosis of different ascites causes are differen,so it is reveal a higher clinical directive significance about the cause of ascites.The diagnosis usually combined with clinical manifestation,laboratory imaging examination and pathological examination.The rate of small tumors by imageological examination is low,pathological examination is is an invasive test.However,laboratory tests of ascites are convenient,economic,fast and no trauma,so it been widely used in differentiating between malignant and benign ascites,it is not clear in how to improve the accuracy of differential diagnosis by combined detection.Objective:Review literature about the laboratory tests for identification of benign and malignant ascites.Find a examination which have most ensitivity and accuracy in dentification of benign and malignant ascites.Methods:Use”ascites,benign and malignant,diagnosis,differential diagnosis,total protein,Lactate dehydrogenase,adenosine deaminase,glucose,free fatty acids,cholesterol,tumor marker,vascular endothelial growth factor,fibronectin,alpha1-antitrypsin epithelial cadherin,telomeric,thymidine kinase,repeat amplification protocol” as keywords for searches.Find out the ascites about dentification of benign and malignant ascites,and make an summary.Conclusion:Ascites routine inspection plays an important role in distinguish ascites property.Ascetic cytological examination is the gold standard for diagnosis of malignant ascites,but the diagnostic sensitivity is low.Ascites SAAG and lactate dehydrogenase have certain value in diagnosis of benign and malignant ascites,but the diagnosis value is limited in diagnosis of tuberculous and malignantascites.Free fatty acid in ascites can be used for the identification of breast or prostate cancer and other related metabolic tumor.Glucose,cholesterol plays an important role in benign and malignant ascites examination.Ascites tumor markers of malignant ascites in the diagnosis of specific degree is higher,but the sensitivity is low.Vascular endothelial growth factor,fiber adhesion proteins,telomerase,epithelial type calcium adhesion protein have high sensitivity and specificity in the diagnosis of benign and malignant ascites.The expression of alpha1 antitrypsin and thymidine kinase have related to the malignant cells.But the research on the clinical value of diagnosis of benign and malignant ascites is less,so it still need further research.Combined a variety of laboratory tests can improve the diagnostic value of benign and malignant ascites obviously,the combination of one or more indexes which can distinguish malignant ascites and tuberculous ascites on the basis of SAAG and LDH can improve the accuracy of differential diagnosis of benign and malignant ascites.Joint detection of SAAG and cholesterol can significantly improve the accuracy and specificity of liver cirrhosis and liver cancer ascites.Joint Ascetic cytological examination with tumor markers can significantly increase the detection rate of malignant ascites.Combined detection of multiple tumor markers can improve the sensitivity and accuracy of the diagnosis about benign and malignant ascites.