Research Progress Of Signal Transduction Pathway In Philadelphiachromosome-like Acute Lymphoblastic Leukemia

Background:Acute lymphoblastic leukemia(ALL)is a heterogeneous disease with a complex pattern of molecular changes including fusion proteins,copy number alterations,and gene mutations.With the development of Gene sequencing,the risk of the disease is more clear,and treatment is more accurate.So the event-free survival of patient has been improved,but there are still some patients with poor prognosis.In 2009 Boer at.al find that a subgroup of B-cell precursor ALL(BCP-ALL)with a gene expression profile similar to BCR-ABL1(Philadelphia chromosome;Ph)-positive ALL,but lacking the BCR-ABL1 fusion gene,has been described and found to be associated with inferior outcomes compared to those of other subtypes of BCP-ALL,through double-loop cross-validation method.The subtypes of BCP-ALL is named Philadelphia chromosome–like acute lymphoblastic leukemia or ph-like ALL,BCR-ABL like ALL.Objective:By reviewing the common signal transduction pathways and gene expression of ph-like ALL,we can provide a reference for better diagnosis and treatment of ph-like ALL.Method:Use "Ph-like acute lymphoblastic leukemia,JAK,CRLF2,ABL,IKZF1,PAX5" and other related keywords to find out about ph-like ALL related literature in CNKI,CBM and Pubmed.Results:Retrieve a total of 152 articles,except with acute lymphocytic leukemia unrelated 83 articles,included 69 articles.Conclusion:There are many studies about ph-like acute lymphoblastic leukemia,but the diagnosis of ph-like is still lacking a unified standard.We can find some ph-like patients through few common chromosome rearrangement,gene mutation and other characteristics.Whether join the tyrosine kinase inhibitor in the treatment of ph-like is the direction of clinical trials.