Meta-analysis Of Curative Effect And Clinical Research Of Shenfu Injection On Early Volume Resuscitation In Patients With Septic Shock

Objective:Using the method of Meta analysis to analyze the related research what has been published at home and abroad about the shenfu injection in the treatment of sepstic shock patients clinical curative effect of early fluid resuscitation,and to comprehensive quantitative analysis of the related research,and hope for providing a scientific basis effective treatment of clinical treatment for patients with sepstic shock in the future.Methods:(1)according to the requirement of the systematic review to make a comprehensive reasonable retrieval strategy;(2)according to the requirement of the systematic review,formulate strict Inclusion criteria and exclusion criteria standard,the literature should be included in the study of the characteristics of the object of study the intervention study of the research object of outcome indicators,etc.;(3)according to the requirement of the systematic review according to the randomized controlled trial of quality evaluation standard for all included in the study of literature to the risk of bias assessment;(4)to extract the literature data,made with the international Cochrane Review application Manager 5.3 software,according to the type of the result of literature index to confirm the analysis method,using the funnel plot to assessment Published bias.Results: The study participants included 15 articles,a total of 1088 person into the group of patients.Meta analysis results show that:(1)Shenfu injection in the treatment of sepstic shock of early fluid resuscitation in patients with clinical curative effect observation indexes in the combined effect of 24 h urine volume inspection: MD = 0.46,95% CI is[0.20,0.72],the statistical significance test Z = 3.49,P = 0.0005,the two groups had significant difference;(2)Shenfu injection in the treatment of sepstic shock of early fluid resuscitation in patients with clinical curative effect observation indexes in 24 h combined effect of Sc VO2 quantity inspection: MD = 4.61,95% CI is [2.67,6.55],the statistical significance test Z = 4.66,P < 0.00001,the two groups had significant difference;(3)Shenfu injection in the treatment of sepstic shock of early fluid resuscitation in patients with clinical curative effect observation index of 24 h combined effect of MAP quantity inspection: MD = 6.62,95% CI is [2.10,11.13],the statistical significance test Z = 2.87,P= 0.004,the two groups had significant difference;(4)Shenfu injection in the treatment of sepstic shock of early fluid resuscitation in patients with clinical curative effect observation indexes in 24 h combined effect of Lac quantity inspection: MD = 0.72,95% CI [1.10,0.33],statistically significant test Z = 3.67,P=0.0002,the two groups had significant difference;(5)Shenfu injection in the treatment of sepstic shock of early fluid resuscitation in patients with clinical curative effect observation indexes in 3 d APACHEII scores of consolidation effect quantity inspection: MD = 2.52,95% CI[3.56,1.49],statistically significant test Z= 4.76,P< 0.00001,the two groups had significant difference;(6)Shenfu injection in the treatment of sepstic shock of early fluid resuscitation in patients with clinical curative effect observation index of 28 d consolidate effect quantity inspection: the mortality of RR = 0.84,95% CI is [0.70,1.00],the statistical significance test Z = 1.94,P = 0.05,the two groups had significant difference.Conclusion:(1)By the Meta-analysis of curative effect of Shenfu injection on early volume resuscitation in patients with Septic Shock,The effect of shen fu Injection in the treatment of sepstic shock patients of early resuscitation clinical curative effect in improving the 24 h urin、MAP、Sc VO2、3d APACHEII scores、Lac and 28 d mortality has certain curative effect;(2)The quality of the literature for shen fu injection in the treatment of sepstic shock patients clinical curative effect remains to be improved,especially for estimation of sample size、 blinded and the randomized clinical trial design;(3)the literature rarely mentioned adverse drug reaction,can’t provide reliable safety evidence for clinical.