Clinical Analysis Of Hematopoietic Stem Cell Transplantation In The Treatment Of Patients With Non-hodgkin's Lymphoma

Objective:To retrospectively analyze the curative effect of hematopoietic stem cell transplantation on non-Hodgkin's lymphoma and to evaluate the prognostic factors of the patients with non-Hodgkin's lymphoma.Methods : All the 38 patients were treated with hematopoietic stem cell transplantation from 2002 to 2016 in the First Affiliated Hospital of Guangxi Medical University.Among them,15 cases were treated with autologous hematopoietic stem cell transplantation,23 cases were treated with allogeneic hematopoietic stem cell transplantation.30 patients were with TBI and 8patients without TBI preconditioning.All of the patients,25 patients had achieved CR and 13 patients hadn't achieved CR.The duration of the study was the death of the patient or the last follow-up time since the patient's transplant time.Results : The median follow-up time of surviving patients was 69.5(4-136)months.All patients were achieved hematopoietic reconstitution after transplantation.The 3-year overall survival(OS)rate was 52% in 38 patients with NHL and progression-free survival(PFS)rate were 50.7% in 3 years.The3-year OS rate in patients who achieved CR before transplantation was 65.7%while 26.9% in the patients who hadn't achieved CR(P = 0.03),and the PFS rates of the two groups were 64.7% and 23.9%(P = 0.01).The 3-year OS rates of patients with Auto-HSCT and Allo-HSCT were 72.2% and 39%,respectively(P = 0.12).Univariate analysis showed pre-transplant disease status and IPI score were the prognostic factors.Multivariate analysis showed that pre-transplant disease status was an independent prognostic factor for OS and PFS.Conclusion:Hematopoietic stem cell transplantation is an effective method for the treatment of NHL.The absence of complete remission is independent prognosis of the independent risk factors after transplantation,therefore,patients who achieved complete remission treated with hematopoietic stem cell transplantation can get a better OS rate and PFS rate.