Safety And Efficacy Of Hepatectomy Combined Intraoperative Electron Radiotherapy For Liver Cancer: A Propensity Score Matching Analysis

Objective:To explore the safety and efficacy of patients with PLC undergoing hepatectomy combined IOERT after propensity score matching.Methods:From 2009 to 2012,The clinical data of 18 patients with primary liver cancer undergoing hepatectomy combined IOERT were analyzed,including 16 cases of HCC and 2 cases of ICC confirmed by postoperative pathology.By using the Propensity score matching model(1:2),36 patients were screened from patients receiving hepatectomy alone during the same period as control group(32 cases of HCC,4 cases of ICC).To compare intraoperative and postoperative complications,and early postoperative recurrence(less than 2 years)of HCC patients between two groups.All patients were followed up regularly.Results:All the patients were followed up,and the follow-up rate was 100%.No significant differences were observed in intraoperative bleeding volume,liver function,coagulation function,blood routine examination and postoperative hospital stay between two groups.However,the operative time between two groups was statistically difference(P<0.001).2 patients of combination treatment group developed postoperative complications:1 acute renal failure and 1 hydrothorax.1 patient of control group developed liver wound bleeding.6 HCC cases of combined IOERT group replapsed within 2 years,with the early recurrence rate of 37.5%,while 20 HCC cases of control group replapsed,with the early recurrence rate of 62.5%.There were no statistically significant differences between the two groups(P=0.101).Conlusion:Hepatectomy combined IOERT for patients with PLC was safe.The early recurrence rate of adjuvant IOERT is lower than the hepatectomy alone,but with no statistical significance.