The Research Of Stroke Patients Quality Of Life And Formulate Its Minimal Clinically Important Difference

Objective: To understand the quality of life of patients with stroke and its influencing factors, for the relevant departments to develop measures to improve the quality of life and provide the basis; to develop the quality of life in patients with essential stroke minimal clinically important difference, for the application of quality of life for the clinical curative effect of stroke patients judged to provide reference.Methods: Determination by stroke patient quality of life scale QLICD-ST (V2.0),SF-36 scale questionnaire and stroke patients’ objective indicators,on June 1,2016 to January 30, 2017 of Kunming Medical University First Affiliated Hospital diagnosed and hospitalized stroke patients quality of life determination and objective indexes of copying. Using SPSS 17.0 for data entry and analysis, the main statistical methods include descriptive statistics, t test, variance analysis, multiple linear regression,simple linear correlation, etc. Among them, the multiple linear regression statistical methods to investigate factors affecting the quality of life in patients with essential stroke,correlation analysis was used to investigate the relationship between the scores of life quality and the objective indicators, were used to calibration for foundation and the distribution for the basic research on the method of formulation minimum clinically important difference value (MCID).Results: 1. specific scale QLICD-ST (V2.0) storke patient overall quality of life and quality of every field of life situation: physiological function field 52.22±4.86,psychological function field 45.23±5.78,social function field 61.25±4.22,specific module field 42.82±6.38, scale total score 43.83±2.56. Universal scale determination of SF-36 patients’ quality of life: physiological comprehensive score 57.622±13.69,mental comprehensive score 74.14±13.50. Discharged stroke patients before the field of SF-36 life quality score from high to low is emotional function score of 89.70±21.06, 87.50±13.68 score of physiological function and social function scores of 82.27±8.19,76.98±4.94,the mental health score energy score 76.27±5.31,67.50±30.39, physiological function score of body pain score of 55.09±11.15, general health score 46.14±7.16; compared with the national norm: a field of 8 stroke patients in physical function,bodily pain,general health field than the national norm of low(P<0.05), physiological function, social function and the national norm (basically the same as P>0.05),energy,emotional function and mental health than the national norm(high P<0.05)2. The quality of life of patients): the main influence factors of the main factors influencing quality of life with QLICD-ST (V2.0were age, plasma fibrinogen, clinical type, ketone, economic status, cultural level, high density lipoprotein cholesterol(mmol/L), low density lipoprotein cholesterol (mmol/L), white blood cell count(109/L), total cholesterol (mmol/L), indirect bilirubin (mol/L), serum creatinine(mol/L), high density lipoprotein cholesterol (mmol/L), total cholesteroll (mmol/L),such as nitrite.3. Correlation analysis of quality of life in stroke patients with QLICD-ST2.0 score and clinical biochemistry indexes showed that the alanine aminotransferase(IU/L), aspartate aminotransferase (IU/L), AST/ALT, total cholesterol (mmol/L), free cholesterol (mmol/L), high density lipoprotein cholesterol (mmol/L), low density lipoprotein cholesterol (mmol/L), magnesium (mmol/L), white blood cell count(109/L), lymphocyte percentage%, monocyte percentage%, the percentage of eosinophils%, .basophil percentage, eosinophils (109/L), basophils (109/L), mean hemoglobin (PG). The average hemoglobin concentration (g/l), prothrombin time,thrombin time, activated partial thromboplastin time, international normalized ratio,carotid artery color Doppler ultrasound,are related to the quality of life of QLICD-ST2.0 score.4. The universal scale SF-36 QLICD-ST (V2.0) as the control scale, respectively. Correlation analysis of two scale in all areas between the scores showed that two scale positive correlation between the corresponding field, two scale correlation coefficients were slightly higher than the correlation coefficient between.QLICD-ST in other fields (V2.0) scale used in clinical research.5. The minimal clinically important difference value (MCID): According to 0.5 ES the MCID value: physiological function field 5.50, psychological function field 6.09,social function field 6.01,general module of the total field 5.51,specific module field 5.14, scale total score 5.06.Conclusion: The score of quality of life in patients with stroke is low, the main factors affecting the quality of life were age, plasma fibrinogen, clinical type, ketone,economic status, culture degree, high density lipoprotein cholesterol (mmol/L), low density lipoprotein cholesterol (mmol/L), the number of white blood cell (109/L).Total cholesterol (mmol/L), indirect bilirubin (mol/L), serum creatinine (mol/L), high density lipoprotein cholesterol (mmol/L), total cholesterol (mmol/L), nitrite. Clinical and life quality score of objective indexes for AST/ALT,total cholesterol (mmol/L),free cholesterol (mmol/L), high density lipoprotein cholesterol (mmol/L), low density lipoprotein cholesterol (mmol/L), white blood cell count (109/L) and QLICD-ST(V2.0) scale has positive correlation with SF-36, can be used in the clinical study. To develop a criterion based MCID can be used in clinical research.