The Expression Of SDF-1/CXCR4 In Bladder Cancer And Its Correlation With Negative Costimulatory Molecule PD-L1, Apoptosis And Invasiveness

Objective: To study the SDF-1/CXCR4 expression in bladder cancer tissue and the correlation with negative costimulatory molecule PD-L1,cell apoptosis and invasion.Methods: 118 cases of bladder cancer tissue and para-carcinoma tissue surgically removed in the First People's Hospital of Xianyang City between May 2014 and May 2016 were selected as the research samples.The total RNA was extracted and then reverse-transcribed into cDNA.The expression levels of SDF-1/CXCR4,PD-L1/PD-1,cell apoptosis-related molecules and cell invasion-related molecules were detected.Results: SDF-1 and CXCR4 mRNA expression in bladder cancer tissue were significantly higher than those in para-carcinoma tissue;PD-L1,PD-1,Rec1,Survivin,MRPS5,Nanog,TRPM8,TRPV2,ILK,?-catenin and GUGBP1 mRNA expression in bladder cancer tissue were significantly higher than those in para-carcinoma tissue and positively correlated with SDF-1 and CXCR4 mRNA expression.Conclusion: Highly expressed SDF-1/CXCR4 in bladder cancer tissue was detected in this study,and the expression levels was closely related to the high expression of negative costimulatory molecule PD-L1,pro-proliferation molecules and pro-invasion molecules.SDF-1/CXCR4 can promote the immune escape,proliferation and invasion of bladder cancer cells.