Effect Of The GABAergic Neuron Activity Of Entorhimal Cortex Of Rat On Sensorimotor Gating And Learning Memory

Objective:To investigate the effect of GABAergic neuron activity of entorhimal cortex in rats on sensorimotor gating and active avoidance learning.Method:Bilaterally implanted guide cannulae into the medial entorhimal cortex(MEC)or lateral entorhimal cortex(LEC),the rats were infused with GABA_A receptor agonist muscimol(0.5?g/0.5?L,per hemisphere).The behavioral tests were conducted 30 min after infusion.Result:After muscimol infusion,compared with the saline infused control group,the rats in MEC group shows hyperactivity in the open filed test,more entries into the open and closed arm in the elevated plus-maze test and disruption of the prepulse inhibition at intensity of 73 d B,as well as the deficiency of learning and memory in the two-way active avoidance task and Morris water maze test.Conclusion:The involvement of the entorhinal cortical neuronal activity,especial the medial entorhinal cortex area,has important roles on the spontaneous activity,anxiety,sensorimotor gating,as well as the two-way active avoidance learning and memory of rats.