The Effect Observation Of Dexmedetomidine Combined With Butorphanol For Patient Controlled Intravenous Analgesia After Laparoscopic Colorectal Cancer Surgery

Objective To evaluate the effect of dexmedetomidine combined with butorphanol for patient controlled intravenous analgesia(PCIA)after laparoscopic colorectal cancer surgery.Methods This study was approved by yantai yu huang ding hospital affiliated to Qingdao university medical college medical ethics committee,and we had signed informed consent with the patient or family members before the operation.One hundred patients with laparoscopic colorectal cancer surgery with general anesthesia,ASA I—II grade,were divided into two groups by random digits table:group A and group B,each group with 50 cases.The group A received 0.1?g/kg/h dexmedetomidine,and added 0.125mg/kg butorphanol(not more than 10mg)and 10 mg azasetron.The group B only received0.125mg/kg butorphanol(not more than 10mg)and 10 mg azasetron.Applied patient controlled intravenous analgesia(PCIA)pump continuous infusion gave total 100 ml,background infusion 2ml/h,patient controlled analgesia(PCA)0.5ml,lock time 15 min,analgesia was continued 48 h.Each groups were received 0.5mg butorphanol and 8 mg ondansetron;at 15 minutes before the end of surgery.The group A was received 0.5?g/kg dexmedetomidine by intravenous pumping(10 minutes)after anesthesia induction.At the end of surgery,each groups got PCIA.Below were recorded at 2,6,12,24 and 48 h after the beginning of PCIA:analgesia VAS score and ramsay sedation scale(RSS);the total number of button pressing of PCA,additional analgesics cases,adverse effects during postoperative analgesia and satisfaction scores were recorded at 48 h after operation;record the circumstance that we had to use other pain relievers as a remedy of analgesic drugs due to insufficient analgesia,and the types of drugs,usage and dose do detailed records;the effect of side effects during postoperative analgesia and the overall satisfaction of patients after the second day of operation.Using SPSS17.0 statistical software processing,snapping the data through the normality and homogeneity of variance test,using comparative analysis,in the group of repeated measurement variance with group t test compared between groups.P < 0.05 is statistically significant.Results(1)general data: the age,weight,operation time,anesthesia time,and the amount of time spent in the two groups were not statistically significant(P > 0.05).There was no statistical difference between HR,BP,RR,Sp O2,ECG(P > 0.05).(2)the effects of pain and sedation: the VAS scores were statistically significant(P > 0.05)in both groups.There was no statistical significance(P > 0.05)for Ramsay sedation scores in both groups.(3)the number of compressions in 48hs: group A was significantly less than group B,and the difference was statistically significant(P < 0.05).(4)side effect: the incidence of nausea and nausea in group A was significantly lower than in group B,and the difference was statistically significant(P < 0.05).(5)drug supplemental and patient satisfaction: neither group showed any additional pain reliever caused by insufficient analgesia;The overall satisfaction of the group A was significantly higher than that of group B,and the difference was statistically significant(P < 0.05).Conclusion Concentration 0.1?g/kg/h dexmedetomidine with butorphanol has exact effects for patient controlled intravenous analgesia(PCIA)after laparoscopic colorectal cancer surgery,reduce the consumption of the butorphanol and adverse effects,improve patient satisfaction.