Radiotherapy Sequential Or Synchronous Endocrine Therapy For Breast Cancer Patients After Operation:A Meta-analysis

Objective:Using Meta-analysis to systematically evaluate the effectiveness and safety of radiotherapy sequential or synchronous endocrine therapy for breast cancer patients after operationMethods: The relevant studies investigating radiotherapy sequential or synchronous endocrine therapy for breast cancer patients after operation by searching foreign language databases(PubMed and Cochrane Library)and Chinese databases(China National Knowledge Infrastructure,VIP Database,Chinese Biomedical Literature Data and Wanfang Database)were included,then the methodological quality of included studies were evaluated.Meta-analysis was performed using STATA 12.0 software and relative risk(RR)with its 95% confidence interval(CI)were estimated.Results: A total of 14 literatures(4 randomized controlled trials and 10 retrospective cohort studies)involving 2862 breast cancer patients after operation were included.The results showed there is no statistically significant difference between sequential group and concurrent group in terms of ?5-year overall survival(OS)rate [relative risk(RR)=1.00,95% confidence interval(CI):0.93~1.07,P=0.907],?2-year event-free survival(EFS)(RR =1.00,95%CI:0.92~1.08,P=0.909),recurrence(RR =1.07,95%CI:0.86~1.32,P=0.536),distant metastasis(RR =1.09,95%CI:0.89~1.34,P=0.401),pulmonary fibrosis(RR =0.88,95%CI:0.56~1.38,P=0.580),pneumonia(RR =0.81,95%CI:0.41~1.61,P=0.543),skin fibrosis(RR =0.93,95%CI:0.63~1.36,P=0.696).The different significant correlation was also not existed between sequential group and concurrent group in the subgroups of research types,different countries and endocrine therapies.Conclusions: For breast cancer patients after operation,?5-year overall survival,?2-year event-free survival,recurrence,distant metastasis,pulmonary fibrosis,pneumonia and skin fibrosis of sequential group and concurrent group had nosignificant differences.However,included clinical trials are almost retrospective,randomized,high-quality,large sample,multi-center prospective studies are needed for further verification.