Resting-state Functional Magnetic Resonance Imaging Study In First-episode Depression And Subjects At High Risk For Depression

Objective: Using resting-state functional magnetic resonance imaging,we observed the features of brain function in first-episode,medication-naive adult patients with depression and subjects at high risk for depression during resting state,and further to explore the relationships between abnormal brain activity of depressed patients and total depressive severity and symptom clusters,then explored the pathological mechanism of the susceptibility to depression.The purpose was to produce science reference and objective basis for the diagnosis and treatment of depression,and protect the subjects at high risk for depression.Method: 23 first-episode,medication-naive adult patients with depression,26 subjects group at high risk for depression and 15 age,gender matched healthy control group were scanned using3.0T MRI during resting state.ALFF,fALFF,Re Ho analysis were used to detect neural spontaneous activity and the between-group differences in ALFF,fALFF,ReHo values were compared.Then correlation analysis was performed in the ALFF,fALFF and ReHo value of depression group and total depressive severity(HAMD score)and symptom clusters.Results:1.The analysis results of ALFF figure: Comparing with the healthy control group,the depression group showed increased ALFF in the left cerebellum anterior lobe,left postcentral gyrus,left inferior parietal lobule,left superior frontal gyrus and bilateral precentral gyrus,and decreased in the bilateral cerebellum posterior lobe;The subjects at high risk for depression showed increased ALFF in the right cerebellum posterior lobe,and decreased in the right superior frontal gyrus.Comparing with the depression group,the subjects at high risk for depression showed increased ALFF in the bilateral cerebellum posterior lobe,right lingual gyrus,and decreased in the right thalamus,left inferior parietal lobule and left precuneus.In the depression group,the value of ALFF in the left cerebellum anterior lobe was positively correlated with depressive severity and anxiety(P=0.015,0.010);the value of ALFF in the superior frontal gyrus was positively correlated with cognitive disorder(P=0.012);the value of ALFF in the precentralgyrus was positively correlated with hopelessness(P=0.009);the value of ALFF in the superior temporal gyrus was positively correlated with body weight change(P=0.014);the value of ALFF in the right anterior cingulate gyrus was positively correlated with sleep disorders(P=0.015).2.The analysis results of fALFF figure: Comparing with the healthy control group,the depression group showed increased fALFF value in the left inferior frontal gyrus,left postcentral gyrus and right precentral gyrus,and decreased in the bilateral cerebellum posterior lobe and right middle temporal gyrus;The subjects at high risk for depression showed increased fALFF value in the right cerebellum posterior lobe,and decreased in the left middle temporal gyrus and left superior frontal gyrus.Comparing with the depression group,the subjects at high risk for depression showed increased fALFF value in the bilateral cerebellum posterior lobe,left middle temporal gyrus and left lingual gyrus.In the depression group,the value of fALFF in the left cerebellum posterior lobe was negatively correlated with depressive severity and anxiety(P=0.015,0.007);the value of fALFF in the right cerebellum posterior lobe was negatively correlated with hopelessness(P=0.008);the value of f ALFF in the left thalamus was positively correlated with diurnal mood variation(P=0.012).3.The analysis results of ReHo figure: Comparing with the healthy control group,the depression group showed increased ReHo value in the right superior frontal gyrus,bilateral anterior cingulate gyrus and left postcentral gyrus,and decreased in the right putamen,right cerebellum posterior lobe and right superior temporal gyrus;The subjects at high risk for depression showed increased Re Ho value in the left putamen and right anterior cingulate gyrus,and decreased in the left lingual gyrus,left superior frontal gyrus and right superior temporal gyrus.Comparing with the depression group,the subjects at high risk for depression showed increased ReHo value in the right putamen,right cerebellum posterior lobe,right superior temporal gyrus and right cingulate gyrus,and decreased in the left precuneus and left superior frontal gyrus.In the depression group,depressive severity was negatively correlated with the value of ReHo in the left cerebellum posterior lobe(P=0.010);hopelessness was negatively correlated with the value of fALFF in the right cerebellum posterior lobe(P=0.013);diurnal mood variation was negatively correlated with the value of fALFF in the left cingulate gyrus(P=0.014),was positively correlated with the value of fALFF in the left thalamus(P=0.048).Conclusion: Compared with the healthy control group,patients with depression and subjects at high risk for depression had abnormal brain regions in the rest state,including frontal lobe,temporal lobe,parietal lobe,occipital lobe,cerebellum and limbic system.At the same time,partial abnormal brain regions in depression and depression severity and clinical symptoms was linear correlation.So,it evidenced that depression is a disease involving more brain areas andsystems.And we can speculate that these abnormal brain regions may be the potential nerve pathological mechanism of depression and susceptible to depression.