Simulation Study On The Systemic Circulation Of Human Blood

The traditional Chinese medicine pulse diagnosis and meridian acupuncture treatment and so on are related to human blood circulation hemodynamics closely.However,the development of Chinese medicine diagnosis and treatment was limited by the experience and subjectivity of its theory.At present,there are many studies on human blood circulation hemodynamics,but there is no systematic research yet.Thus,in this thesis,a fluid network model of systemic circulation of human blood has established.The model is solved by a 10 times harmonic hemodynamics expression of cardiac output and the average method of adaptive control based on the lumped parameter.The objective of the simulation study is to analyze the relationship between the hemodynamic parameters of the human body and the changes of different organs flow resistance.The study is dedicated to provide some theoretical basis for Chinese medicine diagnosis and treatment.According to the meridian hypothesis of an auxiliary respiratory system,the tissue pressure of viscera branch in the fluid network system will drop when acupuncture on the acupoint of the corresponding visceral meridians.Then the blood flow resistance of the viscera branch is reduced.For the hemodynamics experimental study by acupuncture on Taichong(LR-3)by Takayama et al,the effect of liver flow resistance changes on hemodynamic parameters is studied.With the cardiac index keeping constant,when the flow resistance of liver branch changed in the range of ±25%,the simulation results show that the left arm arterial flow volume increases by 2.84% for a 25% increase of liver flow resistance and decreases by 3.27% for a 25% decrease of it.The right arm arterial flow volume increases by 2.61% for a 25% increase of liver flow resistance and decreases by 3.02% for a 25% decrease of it.Aortic peripheral pressure increases by 2.48% for a 25% increase of liver flow resistance and decreases by 3.09% for a 25% decrease of it.Carotid artery peripheral pressure increases by 2.54% for a 25% increase of liver flow resistance and decreases by 3.16% for a 25% decrease of it.Radial artery peripheral pressure increases by 2.70% for a 25% increase of liver flow resistance and decreases by 3.12% for a 25% decrease of it.The systemic vascular resistance increases by 2.48% for a 25% increase of liver flow resistance and decreases by 3.09% for a 25% decrease of it.The simulation results are in good agreement with Takayama's experimental results,which show the validity of the model and the feasibility of the solve method.On the basis of the above conclusions,the effects of different organs flow resistances were studied on the average flow rate,the aortic pressure,radial artery pressure and the harmonic amplitude when the flow resistance ratio ? is respectively setted to 0.5,1.0,1.5,2.0,2.5 and 3.0.With the cardiac index keeping constant,the results show that the average flow rate decreases with the increase of flow resistance of corresponding branch.The changes of flow resistance of different organs have a certain influence on the flow volume of other organs.The aortic mean pressure increases with the rise of flow resistance of organ branch.When ? is setted to 3.0,the aortic mean pressure increases by 23.29%,16.42%,14.67%,9.69%,9.59% and 7.82% for the flow resistance increase of brain,liver,kidney,stomach,intestine and spleen branch respectively.The flow resistance of liver and kidney branch has the greater effect on the radial artery mean pressure,which respectively increases by 22.85% and 11.17% when ? is setted to 3.0.While the other organ branches have less influence.For the harmonic amplitude of the radial artery pressure,the biggest affecting factor is the brain branch flow.The liver and kidney branch have less influence than the brain.The stomach,intestine and spleen branch have little impact on it.In this thesis,we have found the relationships between the hemodynamic parameters and the changes of different organs flow resistances by the simulation method,which can provide some theoretical basis for the traditional Chinese medicine pulse diagnosis and meridian acupuncture treatment and so on.The research methods in this thesis can provide thoughts for the analysis of pipe network flow problem in the engineering field such as nuclear engineering and technology.