Correlation Analysis Between Serum α-klotho Level And The Development Of Obesity-related Glomerulopathy

ObjectiveThe aim of our study is to detect the level of serum α-klotho in different obese people and to investigate the correlation between serum α-klotho and ORG.MethodsA total of 48 cases of ORG with diagnosed by renal biopsy were enrolled in the study.Forty-eight gender-,age-and BMI-matched obese participants,and 48 obese chronic kidney diease(CKD)patients without ORG were included as controls.The clinical manifestations,laboratory examinations of all three groups were collected,and the level of serum α-klotho protein was measured by ELISA.ResultsThe patients with ORG were characterized by decreased serum secreted α-klotho concentration compared with the controls [572.66(439.92,690.58)pg/ml vs.635.85(559.52,769.20)pg/ml and 690.30(516.15,828.20)pg/ml,P<0.01].Multinomial multiple logistic regression analysis revealed that serum α-klotho(per100pg/ml increased)was independently associated with the prevalence of ORG,and the risk of ORG decreased to 35% in the obese participants(OR=0.652,95% CI:0.487~0.872)and 38% in CKD patients(OR = 0.617,95% CI: 0.453~0.832)respectively.ConclusionsThe level of serum α-klotho is significantly decreased in ORG and associated with the prevalence of ORG independently.Serum α-klotho may be a protective factor in ORG.