The Examination And Significance About The Serum Vitamin D Levels Of Thyroid Nodules And Thyroid Carcinoma Patients

Objective:To understand nutritional status of vitamin D of thyroid nodules / thyroid cancer patients,so that we can further explore the possible pathogenesis of thyroid nodules and thyroid cancer and provide theoretical basis for intervention method by the detection of serum vitamin D levels by Liquid Chromatography-Tandem Mass Spectrometry.Methods: 70 patients were divided into two groups:1.thyroid nodules group 40 cases(12males and 28 females,ultrasonic classification of 3 categories and 3 categories below,needle aspiration biopsy or tissue biopsy suggestive of benign),thyroid carcinoma group 30cases(5males and 25 females,ultrasonic classification of 4 categories or more than 4categories,needle aspiration biopsy or tissue biopsy suggestive of malignant).In addition,30 healthy subjects were selected as healthy group(9 males and 21 females).Results:1.Serum levels of vitamin D in the thyroid carcinoma group was 14.83 ±6.26ng/ml,in thyroid nodules group was 19.08 ± 3.70ng/ml,and 25.87±6.27ng/ml in healthy group.Compared the groups we can see significantly statistical different(P <0.05);2.The deficiencyand inadequate incidence of Vitamin D respectively were 87%and10% of thyroid carcinoma group;the deficiency andinadequate incidence of Vitamin D respectively were 60%and40% of thyroid nodules group,the deficiencyand inadequate incidence of Vitamin D respectively were 17%and70% of healthy group;3.The levels of serum vitamin D in thyroid nodules group were significantly lower than those in healthy group,the difference was statistically significant(Z = 4.8602,P <0.05);4.The levels of serum vitamin D in thyroid carcinoma group were significantly lower than those in thyroid nodules group,the difference was statistically significant(Z =-4.1483,P <0.05);5.The level of serum vitamin D in thyroid carcinoma group was significantly lower than that in healthy group,the difference was statistically significant(Z=-4.5098,P<0.05);6.The levels of serum vitamin D in multiple thyroid nodules were lower than those in single thyroid nodules within the thyroid nodules group,the difference was statistically significant(Z=-2.4589,P<0.05);7.There was no statistically significant difference(t = 0.12,P> 0.05)in serum vitamin D levels between patients who were graded on ultrasound into TI-RADS type2 and type 3.Conclusion:1.The level of vitamin D in this study population was generally low;2.The vitamin D levels of thyroid nodules and thyroid carcinoma patients were significantly lower than healthy people;3.The vitamin D levels of thyroid carcinoma patients are lower t han thyroid nodules patients.