Clinical Research Of Tongjingtie In Treatment Primary Dysmenorrhea With Cold Blood Stasis Syndrome

Objective: To observe the clinical efficacy and objective indexes of dysmenorrhea in the treatment of primary dysmenorrhea(PD)of cold coagulation and blood stasis,and to explore its possible mechanism.Methods: 70 patients with cold coagulation and blood stasis type were randomly divided into treatment group(dysmenorrhea)and control group(warm palace paste).Respectively,after 1 week before the paste in the Shenque,Guan Yuan,continuous use of 10 days.The changes of menstrual pain,menstrual viscosity,plasma viscosity,and hematocrit(HCT)were measured before and after treatment,and the changes were observed before and after treatment,uterine artery pulsatility index(PI),resistance index(RI),peak systolic / diastolic peak(A/B)of erythrocyte aggregation index,estradiol(E2),progesterone(P).Result:(1)Analgesic effect: the two groups of patients with dysmenorrhea VAS score after the end of the first treatment cycle has decreased(P<0.05),indicating that the recent pain has been effective,after the end of the two cycles of treatment between the two groups(P< 0.05),indicating that with the treatment cycle increased,the treatment group to improve dysmenorrhea VAS score was significantly higher in the control group.(2)The clinical symptoms of TCM were 91.1% in the treatment group and 78.7% in the control group.There was significant difference between the two groups(P<0.05).After treatment,the TCM syndrome scores of the two groups were decreased(P<0.05).The degree of dysmenorrhea and the effect of Wong-Baker in the treatment group were significantly higher than those in the control group(P<0.05).(3)Menstrual quality,color changes: after treatment,the treatment group by color,quality score compared with before treatment decreased,the group comparative analysis,the difference was statistically significant(P<0.05),indicating that dysmenorrhea can improve blood stasis Happening.(4)Laboratory indicators: After treatment,the two groups of patients with high shear viscosity,low shear viscosity,plasma viscosity,hematocrit(HCT),erythrocyte aggregation index content was not obvious,between groups,the difference was not statistically significant(P<0.05).The PI,RI and A / B values of uterine artery were lower than those before treatment,and the difference was statistically significant(P<0.05).The two groups were statistically analyzed(P<0.05).There was no significant difference in the levels of estradiol(E2)and progesterone(P)in the two groups after treatment,and there was no significant difference between the two groups(P>0.05).(5)The economic aspects: two treatment methods can improve dysmenorrhea symptoms,dysmenorrhea paste than the warmth of the table more economical and affordable.Conclusion: Dysmenorrhea has a good analgesic effect,its mechanism may be related to improving the state of menstrual blood stasis,increase uterine artery blood flow,improve uterine local blood circulation.Two kinds of treatment methods,dysmenorrhea paste than the warmth of the paste more affordable.