Progress In The Study Of Dendritic Cells As A Target In The Treatment Of Multiple Sclsrosis

Multiple sclerosis(MS)is considered to be a predominantly T-cell-mediated disease,and emerging evidence indicates that dendritic cells(DCs)have a critical role in the initiation and progression of this debilitating condition.DCs are specialized antigen-presenting cells that can prime naive T cells and modulate adaptive immune responses.Under the regulation of signal pathways,DCs can produce kinds of cytokines,co-stimulatories and enzymes.Their powerful biological functions indicate that these cells can be exploited by immunotherapeutic approaches.Therapies that inhibit the immunogenic actions of DCs through the blockade of proinflammatory cytokine production and T cell co-stimulatory pathways are currently being pursued.Furthermore,novel strategies that can regulate dendritic cell development and differentiation and harness the tolerogenic capacity of these cells are also being developed.Here,I will introduce the DCs function and subsets,and the relationship between DCs and MS,as well as the targets of DCs to treat MS.