A Clinical Study On The Changes In MSTN Level Among Gastric Carcinoma-associated Cachexia During Different Postoperative Stages

Objective: To observe the changes in MSTN level among gastric carcinoma-associated cachexia during different postoperative stages,to investigate the relationship between MSTN and cachexia,and to preliminarily understand the effect of postoperative chemotherapy on MSTN level changes.Methods: We screened 78 cases of first diagnosed gastric malignant tumor in Department of general surgery in our hospital from January 2016 to December 2016.Inclusion criteria:patients whose pathological diagnosis has been confirmed as gastric malignancy and can and is agreed to undergo surgical treatment.Exclusion criteria: 1.Patients with history of anticancer therapy(such as radiotherapy,chemotherapy and other related treatment).2,the first half of the hospital experienced surgical treatment of patients.3,simultaneous merger of other systemic tumors or other organ metastasis.4,hospitalized with acute and chronic infection.5,at the same time with severe heart,liver,brain,lung,kidney or metabolic diseases.6,combined with other diseases that can cause cachexia.7,during the trial,lost access or death,resulting in incomplete information.According to the Scored Patient Generated Subjective Global Assessment(PG-SGA),subjects were divided into gastric carcinoma-associated cachexia group(experimental group)and gastric carcinoma non-cachexia(control group).ELISA was applied to detect the serum myostatin levels preoperative,1w postoperative and 3m postoperative in experimental group and control group.Then other indicators,such as height,weight,hemoglobin,total protein,albumin and C-reactive protein,were measured and recorded.Results:1.Significant difference was observed in each nutritional indicators of preoperative between GCC group and GCNC group(p<0.05),while no significant difference was found in the results of 1w and 3m postoperative between two groups(p>0.05);2.The MSTN levels in GCC group preoperative(2.36±0.32 to 1.36±0.42),1w postoperative(2.11±0.24 to 1.11±0.29)and 3m postoperative(2.02±0.25 to 1.06±0.51)were significantly higher than the respective results in GCNC group;The levels of serum myostatin(MSTN)in human gastric cancer cachexia(GCC)group were higher than those in non cachexia(GCNC)group of gastric cancer patients at the same period,and the level of serum myostatin(MSTN)was higher.3.No correlation between MSTN levels and patient general condition(height,weight)and the parameters of the tumor(site,clinical stage and pathological type)in GCC group and GCNC group was discovered;4.Regardless of cachexia,the MSTN level in gastric cancer patients with chemotherapy was higher than those with no chemotherapy(p<0.05).In patients with gastric cancer,the level of serum myostatin in patients with gastric cancer is higher than that in patients with gastric cancer and non cachexia patients.Conclusions: Descending tendency was observed in the preoperative,1w postoperative and 3m postoperative MSTN levels in gastric carcinoma-associated cachexia;Postoperative chemotherapy can elevate the serum myostatin level.