The Short-term Effect Of Cigartte And Coffee On Regional Cerebal Blood Flow Measured With Arterial Spin Labeling

Purpose To investigate the short-term effects of smoking on regional cerebral blood flow(rCBF)in healthy adults.Methods41 healthy male volunteers(age range 22~55 years old,average age36.6±11.8 years old)were divided into two groups:21 volunteers with smoking habit were selected into smoking group,20 volunteers without smoking habit were selected into non-smoking group.All of them were performed with smoking test.Before and after test,measuring rCBF of occipital lobe,frontal lobe,temporal lobe's gray matter and halamus,basal ganglia with 3D-arterial spin labeling technology(3D-ASL).Results(1)rCBF of 41 volunteers had no significant difference(P>0.05)before and after smoking.(2)21 Smokers showed a lower rCBF than 20 non-smokers before smoking and rCBF in region of bilateral occipital lobe,temporal lobe,thalamus,left basal ganglia had a significant difference(P<0.05)?Conclusion To detect the short-term effect of smoking on gray matter rCBF in healthy adults based on 3D ASL technology,we found that though somking had no short-term impact on rCBF it can lead to rCBF's reduction in the long run.Purpose To investigate the short-term effects of drinking coffee on regional cerebral blood flow(rCBF)in healthy adults.Methods19 volunteers(age range 22~27 years old,average age 24.4±1.4 years old)were performed with drinking coffee test.Before and after test,measuring rCBF of occipital lobe,frontal lobe,temporal lobe's gray matter and halamus,basal ganglia with 3D-arterial spin labeling technology(3D-ASL).Results rCBF of 19 volunteers in region of bilateral occipital lobe,frontal lobe,temporal lobe gray matter and thalamus,basal ganglia showed a significant decrease(P<0.05)after drinking coffee.The decline rate were 14.5%(right)?16.5%(left)?11.6%(right)?11.7%(left)?17.6%(right)?15.7%(left)?14.0%(right)?14.3%(left)?14.4%(right)?15.4%(left),respectively.rCBF in the right temporal lobe had a significant change.Conclusion To detect the short-term effect of intaking coffee on gray matter rCBF in healthy adults based on 3D ASL technology,we found that drinking coffee can lead to a acute reduction in rCBF.