Analysis On Lnfluencing Factors Of Hepatitis C Chronic

Purpose: The aim of this research was investigating the clinical and epidemiological characteristics of cirrhosis after hepatitis C,and to explore the influence factor of Hepatitis C cirrhosis.This research provide a scientific basis for clinicians to develop a reasonable treatment plan to reduce cirrhosis and incidence of treatment to improve the efficacy and quality of life of patients.Methods: We Collected 219 patients as the object of study,and these patients diagnosis chronic hepatitis C and cirrhosis after hepatitis C in hospitalization and outpatient in The Third People's Hospital of Jin Cheng form June 2010 to June 2016.For all subjects,there are divided into two groups according to 2015 Updated "Hepatitis C Prevention Guide" and patients with clinical symptoms,such as signs,biochemical tests,imaging findings.Namely the case group for patients with hepatitis C after cirrhosis,the control group for patients with chronic hepatitis C.(ALT,AST,ALB),lipid metabolism(TC,TG)were measured by fasting venous blood,and the body mass index was collected.Fasting blood glucose(FBG)and hepatitis C antibody,HCV-RNA determination,hepatitis C genotyping.Finally,the data were analyzed statistically.Results: The results of this research show that:(1)the ratio of male to female is 1: 1.46,59.36% for female and 40.64% for male respectively.(2)The proportion of patients with cirrhosis after 60 years of age was higher than or equal to 60 years old(62.50%),and the proportion of patients with hepatitis C cirrhosis was 50.70% 27.53%,less than 40 years of age,the proportion of patients with cirrhosis was the smallest,univariate analysis was significant(c2 = 32.390,P <0.001).(3)The proportion of post-hepatitis C patients with cirrhosis was 39.81%,higher than that of patients without cirrhosis(12.50%).(4)The proportion of patients with liver cirrhosis was 40.40%,and the proportion of patients with cirrhosis was 35.29%,the difference was not statistically significant(c2 = 0.514,P = 0.473).(5)the impact of hepatitis C after cirrhosis analysis showed: smoking,diabetes,high blood pressure,not receiving antiviral therapy,AST ?40U/L,PTA<80% and so on can increase the risk of Hepatitis C cirrhosis,the difference was statistically significant(P <0.05).Logistic regression analysis showed that the period of diagnosis,presence or absence of symptoms after infection,diabetes,whether antiviral therapy,AST?40U/L,BMI can increase the risk for cirrhosis(P Value <0.05).Conclusion: In the patients with HCV infection,the period of the diagnosis,having obvious symptoms after infection,diabetes,did not receive regular antiviral therapy and obesity will increase the risk of developing cirrhosis.