The Research On Relationship Among The NLR?RANKL And Osteoporosis In Postmenopausal Women

Objective: To investigate the relationship between BMD(bone mineral density)?NLR(nutrophil lymphocyte ratio)?RANKL(receptor activator of NF-?B ligand)?E2(estradiol)and Bone turnover marker(BTM)in postmenopausal women.Methods: 88 women age 50 to 80,who living in the east of Fujian area reached 5 years,were enrolled in randomly during January to September in 2016.The clinical data of participants including age?BMI(body mass index)?NLR?E2?BMD at the lumbar spine(LS)and femoral neck(FN)was measured by dual-energy X-ray absorptiometry,RANKL ? BGP(Bone Glaprotein)? NTX(N-terminal telopeptides of type I collagen)using Enzyme chemiluminescence immunoassay.The relationship between NLR,osteoporosis and fracture statiscal methods was analyed.All survey data were performed by Statistical Package for Social Sciences(SPSS)software version 21.0,In the analyses,p<0.05 was deemed to be statistically significant.Results: 1.Age ? BMI ? BGP were not significantly different between the two groups of osteoporotic and non-osteoporotic 2.LS BMD?LS T-score?LS Z-score?FN BMD?E2?NLR?RANKL(P<0.001)were different between the two groups,and the LS BMD?LS T score?LS Z-score?FN BMD,E2 levels were lower,but the NLR?RANKL?NTX levels were higher in the osteoporosis group.3.Age?BMI?BGP?E2 were not significantly different between the fracture group and no fracture group.4.LS BMD?LS T-score?LS Z-score?FN BMD?NLR?RANKL(P<0.001)were different between the two groups,and the LS BMD?LS T score?LS Z-score?FN BMD,E2 levels were lower,but the NLR?RANKL?NTX levels were higher in the cataclasis group.5.Circulating NLR was significantly related to BMD(LS BMD: r =-0.501;LS T-score: r =-0.583;LS Z-score: r =-0.567;FN BMD: r =-0.559),E2(r=-0.339)and RANKL(r=0.581),NTX(r=0.45).Circulating RANKL was significantly related to BMD(LS BMD: r =-0.49;LS T-score: r =-0.557;LS Z-score: r=-0.515;FN BMD: r =-0.62);E2(r=-0.336)and NTX(r=0.932).E2 was significantly related to BMD(LS BMD: r=0.443;LS T-score: r=0.44;LS Z-score: r=0.375;FN BMD: r=0.471).6.Control for Age,BMI,BTM,RANKL,E2,NLR was significantly related to BMD(LS BMD:PC=-0.366,P=0.01;FN BMD:PC=-0.406,P<0.01);but control for Age,BMI,BTM,E2,and NLR,NLR was not related to LS BMD and FN BMD.Control for Age,BMI,BTM,E2,RANKL was significantly related to BMD(LS BMD:PC=-0.336,P=0.002;FN BMD:PC=-0.441,P<0.01).Control for Age,BMI,BTM,E2,RANKL and NLR,E2 was si-gnificantly related to BMD(LS BMD:PC=0.24,P=0.03,FN BMD: PC=0.254,P=0.021).7.Logistic Regression analysis showed that,NLR levels were significantly related to fragility fracture(OR=2.373).Conclusion: 1.NLR may play a big part in bone remodeling,High levels of RANKL increased osteoporosis risk.2.NLR might become independent predictors of fracture.It can be used as the evaluation index of fracture in in postmenopausal women 3.NLR might influence bone remodeling by levels of RANKL.4.Estradiol played play a big part in post-menopause osteoporosis.It might not only be effect on bone remodeling by RANKL,but inhibit bone resorption by the other way.