Study On The Relationship Between Serum Homocysteine And Cerebral Microbleeds In Patients With Acute Atherosclerotic Cerebral Infarction

Objective:To study the relationship between serum homocysteine and cerebral microbleeds in patients with acute atherosclerotic cerebral infarction.Methods:A total of 129 patients with acute atherosclerotic cerebral infarction were enrolled in the Department of Neurology of our hospital from April 2015 to April 2016.According to the magnetic susceptibility weighted imaging,the patients were divided into CMBs group and without CMBs group.Record the general clinical data of patients,laboratory test results,imaging data characteristics,compare the differences between the data.The variance analysis,chi-square test,rank sum test were used to compare the risk factors of cerebral microbleeds,logistic regression analysis was used to analyze the independent risk factors of cerebral microbleeds.Results:Of the 129 patients enrolled in the study,39(48.8%)had CMBs.The number of CMBs is 1-13,with an average of 3.31.The number of CMBs was 1 in 12 patients,2-5 in 18 patients,>6 in 6 patients.Brain lobe CMBs accounted for 20.5%,deep microbleeds accounted for 51.3%,the rest is mixed.According to the patients with or without CMBS divided into two groups,there were significant differences in hypertension(P=0.034),Diabetes Mellitus(P=0.002),old Lacune Infarction(P<0.001),White Matter Lesions(P<0.001)and serum homocysteine level(P<0.001)between the two groups.Conclusion:In patients with cerebral infarction,cerebral microbleeds are common to observe.Magnetic sensitive sequences play an important role in the detection ofmicrobleeds.Hypertension,diabetes mellitus,old Lacune Infarction,white matter lesions,serum homocysteine levels are associated with microbleeds in patients with acute atherosclerotic cerebral infarction.Both the old stalk and serum homocysteine levels are independent risk factors for microbleeds in patients with acute cerebral infarction.Both the old Lacune Infarction and serum homocysteine levels are independent risk factors for microbleeds in patients with acuteatherosclerotic cerebral infarction.