Value Of TI-RADS,Virtual Tough Tissues Quantification And Ceus In Differential Diagnosis Of Benign And Malignant Thyroid Nodules

Objective To assess the value of thyroid imaging reporting and data system(TI-RADS),virtual tough tissues quantification and contrast-enhanced ultrasonography in differential diagnosis of benign and malignant thyroid nodules.Methods TI-RADS,VTQ and CEUS were performed in sixty-nine thyroid nodules in sixty-six patients before operation.The manifestations of CEUS were observed and analyzed.VTQ was used to measure shear wave velocity(SWV).The area under the curve(AUC)and diagnostic cut-off point were obtained by using a receiver operating characteristic(ROC)curve analysis.The sensitivity,specificity,positive predictive value,negative predictive value and degree of accuracy of each and pairwise modality were calculated.Results In 69 thyroid nodules,37 nodules were benign and 32 nodules were malignant.The sensitivity,specificity,positive predictive value,negative predictive value and degree of accuracy of TI-RADS were 78.13%,70.27%,69.44%,78.79%,73.91%,respectively.With a diagnostic cut-off value of 2.55m/s for SWV value,AUC was 0.808.The sensitivity,specificity,positive predictive value,negative predictive value and degree of accuracy of VTQ were 87.50%,86.49%,84.85%,88.89%,86.96%,respectively.The sensitivity,specificity,positive predictive value,negative predictive value and degree of accuracy of CEUS were 65.63%,91.89%,87.50%,75.56%,79.71%,respectively.The sensitivity,specificity,positive predictive value,negative predictive value and degree of accuracy of VTQ combined with CEUS were 93.75%,78.38%,78.95%,93.55%,85.51%.The sensitivity of VTQ in diagnosis of benign and malignant thyroid nodule was the highest and the specificity of CEUS was the highest in three methods separately.The sensitivity of VTQ combined with CEUS in diagnosis of benign and malignant thyroid nodule was not only higher than another two combinations,but also higher than any one of the three methods.Conclusions Three examinations have some value in differential diagnosis of benign and malignant thyroid nodules.The sensitivity of VTQ combined with CEUS is the highest.It is a dependable method in differential diagnosis of benign and malignant thyroid nodules.