Is Essential Tremor A Neurodegenerative Disease? Role Of Neuropathological Assessment And Neuroimaging In Essential Tremor

Till date,Essential Tremor(ET)is known as the most common pathological tremor in human.There has always been an uncertainty as to whether ET is simply a mono-symptomatic disorder.But in the recent years,studies have proven that it is more than just a mono-symptomatic disorder.It is a progressive condition,clinically heterogeneous and associated with clinical features of both motor and non-motor elements.This review briefly describes the current information on ET,the role of neuropathological and neuroimaging findings on the disease.Several postmortem histopathological and MRI-based studies have been included.Among the MRI studies,the most specific for addressing neurodegeneration are VBM,DTI,and RS-fMRI.