| Objective Nonarteritic anterior ischemic optic neuropathy(NAION)of using SD-OCT and EDI OCT in patients with retinal and choroida morphology were detected,understand the changes in the characteristics of patients with retina and choroid before and after treatment.Research of choroida thickness in patients with NAION,the correlation of retinal thickness and visual field.At the same time,whether there are differences between patients the choroid and retinal thickness and the health of people,to assist in the diagnosis and evaluation of therapeutic effect and prognosis.Methods A prospective cohort study was carried out in Tianjin Eye Hospital from July 2015 to Nov 2016.Thirty-six eyes of 36 patients with acute optic neuritis were enrolled as optic neuritis group and 42 eyes of 21 healthy subjects with matched age and gender were included in the normal control group.The mean thickness of retinal nerve fiber layer(RNFL)and choriod in superior,inferior,nasal and temporal quadrants at 3.4mm around optic disc was measured,and the mean thickness of RNFL,ganglion cell layer(GCL),inner plexiform layer(IPL),inner nuclear layer(INL),outer plexiform layer(OPL),outer nuclear layer(ONL)and photoreceptor layer also was measured by EDI OCT.Pattern visual evoked potential(P-VEP)and visual field were examined in all the individuals,the correlations of mean defect(MD)with the thickness of RNFL,choroid and the thickness of RNFL,GCL,IPL,INL,OPL,ONL,photoreceptor layer at macular area were evaluated.Results1、The thickness of the superior,inferior,nasal,temporal and mean RNFL in the NAION group was significantly lower than that before treatment(P <0.05),and the difference was statistically significant(P <0.05)).In the NAION group,the thickness of the choroida around the optic disc was better than that before the treatment,and the difference was statistically significant(P <0.05).NAION patients in the treatment after 0.5 months compared with the control group,the thickness of choroid around the optic disc in the superior,inferior,nasal,temporal were thicker,the difference was statistically significant(P <0.05).2、The values of RNFL,GCL and IPL at 1 mm area around macula of the NAION group were significantly lower than those before treatment(P <0.05).Compared with the normal control group,the values of RNFL,GCL and IPL were significantly thinning in the macular area of 0.5,1,2,3,and 6 months in NAION group(P <0.05).The thickness of GCL and IPL at 3 mm area around macular of 0.5,1,2,3,and 6months after treatment were significantly lower than those before treatment(P <0.05).3、The mean thickness of the superior,inferior,nasal and the mean RNFL around the optic disc was correlated with the MD(P <0.05).There was no significant correlation between RNFL,GCL,IPL,INL,OPL,ONL and photoreceptor layer thickness at 1、3mm area around macular.4、The latency of P100 was(134.55 ± 13.83)seconds in the NAION group and that in the control group was(90.59 ± 5.20)seconds,showing significnat difference(t=14.508,P<0.05).5 、 The correlation analysis showed that there was a positive correlation between RNFL,GCL and log MAR BCVA at 1 mm of macular area in NAION group(r=0.469、0.545,P <0.05).The GCL was positively correlated with log MAR BCVA in 3 mm of macular recess(r =-0.562,P < 0.05).Conclusion1 、 EDI OCT can reflect the RNFL,choroid thickness around the optic disc and thining of various layers of retina at macular area in NAION eyes,It is a meaningful addition to clinical examination,the diagnosis of NAION have a better role in the diagnosis.2、There was a positive correlation between the MD and the RNFL,choroid thickness around the optic disc and various layers of retina at macular area.3、The latency of VEP in NAION patients was longer than control groups,but it is not specific,with the help of other auxiliary means to complete the diagnosis of this disease. |
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