Biomimetic Mineralized Sr-HA On Porous Poly(L-lactide) Acid Scaffolds For Enhanced Cell Adhesion And Repair Of Bone Defect

Tissue engineering is a blend of basic technology and basic methods of life science and engineering.Building implant model with a biological activity in vitro is implanted into the body to repair tissue defects and replace organs.Hydroxyapatite as a new biomaterial can enhance the replication and differentiation of osteoblasts after being incorporated strontium.Biomimetic mineralized Sr-doped HA PLLA scaffolds with precise structures were fabricated.Such composite scaffolds contain a high quality mineral coating on the surface.These composite scaffolds can mimic the composition and structure of the natural bone extracellular matrix and provide a more biocompatible interface for bone regeneration.The composite scaffolds were characterized using scanning electron microscopy,Fourier transform infrared spectroscopy,X-ray diffraction,and pressure resistance testing.Static contact angle and protein adsorption tests show that the composite scaffold materials improve the hydrophilicity obviously,protein adsorption quantity increased obviously.ALP tests showed that the scaffolds exhibited high osteogenic properties.In vitro and in vivo experiments revealed that the scaffolds have good biocompatibility,enhanced osteoblast cells proliferation and differentiation,and induced bone tissue regeneration.