Development Of 3D Printing Aspirin Quick Release Sustained-release Double-layer Tablets

Taking aspirin as a model drug,the feasibility of the controlled release of aspirin tablets was discussed,which was based on the individual demand of 3D printing technology.The experiment selected 10000mPa.s hydroxypropyl methyl cellulose(HPMC10000)and polyacrylic acid(PAA)as a hydrophilic matrix sustained-release layer;hydroxypropyl methyl cellulose 100 mPa.s(HPMC100)as a quick release layer binder,sodium carboxymethyl starch(CMS-Na)and sodium carboxymethyl starch(SSG)as a quick release layer disintegrating agent,the use of 3D printer to print the slow release of aspirin tablets.Select 10%(w/v)and polyvinylpyrrolidone(PVPK30)as a quick release layer binder,crosslinking sodium carboxymethyl cellulose(CC-Na)as a quick release layer disintegrating agent,hydroxypropyl methyl cellulose(HPMC 100)as the matrix material release layer,with the traditional press pressing speed of aspirin sustained-release tablet,as contrast agents.The physical and chemical properties of tablets produced in two different modes of production(film weight difference,hardness and thickness)and release profile were investigated.The physical and chemical properties of the two tablets are all in the Pharmacopoeia.Comparison of two kinds of drug release curve showed that the ASA-HPMC(14%,W/W)and the press release curve of double layer tablets printing film is similar,and the release rate is higher than the tablet(6%W/W,ASA-HPMC double layer tablets),ASA-HPMC(8%,W/W)and ASA-HPMC(10%,W/W)printing film final release amount increased with hydrophilic matrix HPMC.3D printers print different shapes of tablets with different release profiles,in which the release of the package is higher than the other tablets.