Analysis Of Influencing Factors Of Wearing-off Phenomenon In Parkinson's Disease

Objective:To explore the clinical characteristics and related influencing factors of the wearing-off of the primary Parkinson Disease in order to find out the risk factors and protective factors of the wearing-off,to provide reasonable reference for preventing and slowing down the occurrence of wearing-off.Methods:96 cases with primary Parkinson Disease were respectively divided into the clinical WO(?)group and the clinical WO(-)group according to the definition criteria of clinical WO and the clinical status of patients of the clinical WO(?)group were assessed with 9 questionnaires(WOQ-9).The main factors that may affect the wearing-off included gender,age of onset,smoking,drinking,tea drinking,cumulative medication time of levodopa,equivalent daily dose of levodopa,low density lipoprotein,as well as the level of blood uric acid and so on.Single factor analysis was conducted for the above influence factor and the unconditional logistic regression analysis was conducted for the variable with statistical difference between the two groups.Results:Among the 96 patients,there were 53 males and 43 females,with an average age of(65.11 ± 9.17)years and disease course of(7.25 ± 4.43)years.A total of 53 patients met the standards of the clinical WO definition,accounting for 55.2%,including 29 males and 24 females.In single factor analysis,compared with the clinical WO definition(-)group,there existed difference in the age of onset,course of disease,tea drinking,cumulative medication time of levodopa,equivalent daily dose of levodopa,as well as the level of blood uric acid in the clinical WO defined(+)group(P<0.05).The results of the unconditional logistic regression analysis showed that the cumulative medication time of levodopa was positively correlated with the wearing-off(OR=1.608,P<0.01).The level of serum uric acid(OR=0.979,P<0.01)and the history of tea-drinking(OR=0.034,P<0.01)were negatively correlated with the wearing-off.Conclusion:For the patients with longer cumulative medication time of levodopa,the incidence of wearing-off is higher and the cumulative medication time of levodopa is an independent risk factor for the wearing-off.While for the Parkinson patients with tea-drinking history and higher level of serum uric acid,the incidence of wearing-off is lower,drinking tea and high level of serum uric acid are independent protective factor for WO.