Clinical Analysis Of 30 Cases Of Neuroendocrine Carcinoma Of The Uterine Cervix And A Literature Review

Objective:To analyze and discuss the diagnosis,treatment and prognosis of neuroendocrine carcinoma of the uterine cervix,in order to provide some clinical data for the diagnosis and treatment of the disease.Methods:The clinical data of 30 neuroendocrine carcinoma of the uterine cervix patients obtained from Jiangsu Cancer Hospital affiliated to Nanjing Medical University from January 2011 to December 2015 was analyzed retrospectively to research its diagnosis,treatment methods and prognosis factors.Kaplan-Meier curve was used to analyze the impact of different clinical stages,lymph node metastasis,tumor infiltration depth,vascular tumor emboli,tumor diameter,treatment methods and levels of serum neuron specific enolization enzyme on overall survival respectively.Results:According to FIGO in 2009,there were 14 cases in I stage,8 in II stage,3 in III stage and 3 in IV stage.Till deadline,2 patients were lost,and in the rest of 28 cases,13 patients occurred distant metastasis in the liver,lung,bone,adrenal,pleura,surface of chest.There were 12 dead cases among the metastasizing patients who had overall survival for 4,5,7,10,12,13,14,17,17,23,24,25 months respectively and corresponding to progression-free survival for 3,2,2,6,7,9,11,9,10,9,12,21 months.Overall survival of 28 patients were 2-57 months and median OS were 15.5 months,progression-free survival were 2-56 months and median PFS were 11.5 months.We Used Kaplan-Meier curve to analyze the influence of different clinical stages,lymph node metastasis,level of serum neuron specific enolization enzyme on OS,and P values were obtained respectively,0.000 for clinical stages,0.037 for lymph node metastasis,0.001 for level of serum neuron specific enolization enzyme,the results had statistical significance,while tumor infiltration depth,vascular tumor emboli,tumor diameter and treatment methods had no impact on OS,P values equaled to 0.801,0.580,0.352,0.435 respectively,Conclusion:Neuroendocrine carcinoma of the uterine cervix is a rare form of gynecological malignant tumor with poor prognosis and easily recurrence,surgery combined chemoradiotherapy might be effective for early stage.Tumor stage,lymph node metastasis were important factors for further prognosis,and the level of serum neuron specific enolization enzyme might be one of the indicators for prognosis monitoring.