Effects Of Nanosilver And Nanozinc Incorporated Mesoporous Calcium-silicate Nanoparticles On The Mechanical Properties Of Dentin

Background:Mesoporous calcium-silicate nanoparticles(MCSNs)are advanced biomaterials for drug delivery and mineralization induction.They could load silver and exhibit significantly antibacterial effects.However,the effects of MCSNs and silver-loaded MCSNs on dentin are unknown.Methods:The nanosilver and nanozinc incorporated MCSNs(Ag-Zn-MCSNs)were prepared by a template method,and their characterizations were tested.Then the nanoparticles were filled into root canals and they effects on dentin were investigated.Results:Ag-Zn-MCSNs showed characteristics of mesoporous materials and sustained release of ions over time.Ag-Zn-MCSNs nanoparticles could adhere well to the dentin surface of root canal walls and infiltrate into the dentinal tubules after ultrasound activation.Ag-Zn-MCSNs showed no significantly negative effects on both flexural strength and modulus of elasticity of dentin,while CH decreased the flexural strength of dentin significantly(P<0.05).Conclusions:These findings suggest that nanosilver and nanozinc could be incorporated into MCSNs using the template method,and the Ag-Zn-MCSNs may be developed into a new disinfectant for the infection control of root canal and dentinal tubules.