Clinical Study On The Traditional Chinese Medicine Syndrome Of Hypertension With Obstructive Sleep Apnea Hypopnea Syndrome In Guangzhou Area

ObjectiveTo investigate and hypertensive patients with obstructive sleep apnea syndrome(OSAHS)distribution characteristics of TCM syndrome factors,analysis of hypertensive patients with major syndrome factors associated with gender,age and body mass index(BMI),neck circumference,waist circumference,triglyceride(TG),total cholesterol(TC),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C),diastolic blood pressure(DBP),systolic blood pressure(SBP),high sensitive C reactive protein(hs-CRP),homocysteine(HCY)medullary amino acid relationship between these indicators,in order to provide the basis for the clinical syndrome differentiation,improve clinical curative effect.MethodsThis research data mainly from 2016.1 months to 2017.5 months from City University Hospital of Guangdong Province Traditional Chinese Medical Hospital hypertension OSAHS patients with a total of 215 cases with non OSAHS,hypertension,traditional Chinese medicine and Western medicine according to the diagnosis standard of OSAHS with hypertension group(study group,115 cases)and non OSAHS and hypertension group(control group,100 cases),general the data of questionnaire,questionnaire of TCM syndromes and Epworth sleepiness scale score,measuring waist circumference,height,body mass index.The key of OSAHS with hypertension group(study group,115 cases)for clinical research of TCM syndrome,using four diagnostic methods to collect the data of each patient syndrome,and objective in TCM questionnaire,according to the information,and with the reference to "Chinese medicine clinical research guiding principle of trial",the "diagnostics of Chinese medicine" and "syndrome" to the syndrome classification standard,analysis of TCM syndrome,summarize the common syndrome,and to analyze the impact of the main syndrome elements of gender,smoking and drinking,BMI,TG,TC,HDL-C,LDL-C,DBP,SBP,hs-CRP,HCY and other indicators of data.By using Epidata software and double entry,through the establishment of qualified database logic check.Using statistical software SPSS21.0 data analysis,measurement data using(+ s)form,with normal distribution of data,using independent samples test,or the variance test,the skewness distribution data after logarithmic transformation and then compare.Enumeration data were expressed in percentage form,and chi square test was used to compare between groups.Logistic regression analysis was used to determine the independent risk factors of TCM syndrome distribution.If P <0.05,there was statistical significance.ResultsThe two groups of patients with BMI,neck circumference,waist circumference,DBP,SBP,ESS,HCY,hs-CRP,TC,TG,LDL-C,HDL-C and other indicators after statistical analysis,the difference was statistically significant(P <0.05);there was no significant difference between the two groups in gender,mean age and other disease history(P >0.05);Hypertension and 115 OSAHS patients,45 cases of male patients with smoking,drinking and smoking in 48 cases,2 cases were female,3 cases of hypertension and drinking,so OSAHS patients,male patients with love drinking more than females,the difference was statistically significant(P <0.05);115 cases of OSAHS patients with hypertension syndrome type of phlegm dampness syndrome patients accounted for 41.03%(42/115),which belongs to Qi deficiency patients accounted for 23.33%(32/115),which belongs to the blood stasis syndrome patients accounted for 14.78%(17/115),which belongs to the liver Yang Syndrome accounted for 6.96%(8/115),which belongs to the liver syndrome patients accounted for 5.21%(6/115),belong to yin deficiency syndrome patients accounted for 4.34%(5/115),which belongs to Yang deficiency patients accounted for 2.61%(3/115),which belongs to blood deficiency patients accounted for 1.74%(2/115).The distribution of TCM syndromes visible,phlegm,Qi deficiency and blood stasis is the main syndrome of OSAHS with hypertension;hypertension combined with OSAHS group and non OSAHS group of hypertensive patients with BMI,HCY,TC,blood pressure,TG,LDL-C,Min,SaO2,HDL-C and other indicators comparison,differences in statistical significance(P < 0.05).Among them,the phlegm dampness syndrome occupied 36.52% in hypertension combined with OSAHS group,Qi deficiency syndrome occupied 27.83%,blood stasis syndrome occupied 14.78%,and it was the three most widely distributed TCM syndrome type.And found by Logistic regression analysis:Drinking history,TG and hs-CRP are the independent risk factors of blood stasis;sex,alcohol,HDL-c,HCY and TG are independent risk factors of qi deficiency syndrome;sex,smoking,hs-CRP and TG are independent risk factors of phlegm dampness syndrome(P < 0.05).Is still in the initial stage of TCM syndrome type of hypertension combined with the study of the distribution of OSAHS,affected by the disease symptom index dispersion factors,has not yet formed a unified TCM,the study of phlegm dampness syndrome is also a lack of specificity,and can not be completely combined with OSAHS as the evaluation standard.ConclusionOSAHS with hypertension,the prevalence rate of male was more than female,and the men and women of different hobbies are closely related,OSAHS with hypertension group BMI,neck circumference,waist circumference,hs-CRP incidence was higher than that of control group(OSAHS patients without hypertension);OSAHS with hypertension group serum high density lipoprotein(HDL-C)levels were significantly lower than the control group(OSAHS patients without hypertension)suggest that these factors may have is one of the most important factors affecting the occurrence of OSAHS with hypertension.Sleepiness in hypertensive patients with OSAHS group were the most weight;distribution of hypertension in patients with TCM syndrome type group with OSAHS shows a certain regularity of phlegm dampness,Qi deficiency and blood stasis syndrome is the common syndrome in hypertensive patients.Gender,smoking,hs-CRP and TG have some reference value for the diagnosis of phlegm dampness syndrome,and drinking history,TG and hs-CRP have some reference value for the diagnosis of blood stasis syndrome.HDL-c and HCY have certain reference value for the diagnosis of qi deficiency syndrome.