Correlations Between Blood Test Index And Bone Metastasis In Primary Lung Cancer

Objective:To discuss the predictive value and significance of red blood cell distribution width,platelet parameters,blood lipid and lipoprotein a on bone metastasis of primary lung cancer.Methods:We reviewed the clinical data of lung cancer patients who had been diagnosed by needle biopsy or histopathologic analysis without any treatment during the period from June 2006 to December 2017 in the First Affiliated Hospital of Nanchang University,including the patient’s gender,age,pathological type,and blood Erythrocyte distribution width,platelet parameters(including platelet count,platelet distribution width,mean platelet volume,plateletcrit),blood lipids(including total cholesterol,triglycerides,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol),lipoprotein a And treatment methods,Analysis of the correlation between the above factors and the bone metastasis of lung cancer,and use ROC analysis of these factors in the prediction of clinical value of bone metastases of lung cancer.Results:1.In this study,a total of 3460 lung cancer patients were collected,of which1808 were enrolled in this study.There were 444 patients with bone metastases who met the criteria,including 305 males and 139 females,aged 25-87 years,with an average of 60.82±10.73 years.Follow-up duration was 6-38 months,with an average of 11.75±4.06 months.There were 1364 patients without bone metastases,including1027 males and 337 females,aged 26-89 years with an average of 61.84±9.77 years.Follow-up duration was 7-40 months.12.25±4.37 months.2.Univariate analysis results showed that the bone metastasis group and non-bone metastasis group in contrast to peripheral blood red blood cell distributionwidth,platelet count,platelet distribution width,serum lipoprotein a level,lung cancer pathological types,and treatment methods,there was a statistically significant difference(P<0.001),while in contrast to mean platelet volume,,plateletcrit,total cholesterol,triglyceride,low-density lipoprotein cholesterol,and high-density lipoprotein cholesterol levels,There was no statistically significant difference(P>0.05).3.Binary Logistic regression analysis showed that: RDW≥14.55%,PLT≥256.50×109/L,LP(a)≥287.00 mg/L,adenocarcinoma,and non-surgical treatment were independent risk factors for bone metastasis in lung cancer patients(P<0.01)4.alone or combined with each independent risk factors to predict bone metastasis in lung cancer by ROC curve analysis,we found that:(1)single independent risk factor predict bone metastasis in lung cancer,the area under the LP(a)curve was the largest,which was 0.678;(2)Two independent risk factors predict bone metastasis in lung cancer,the area under non-surgical treatment union LP(a)curve was the largest,which was 0.718;(3)Three independent risk factors predict bone metastasis in lung cancer,the area of adenocarcinoma union LP(a)and non-surgical treatment curve was the largest,which was 0.740;(4)Four independent risk factors forecast bone metastasis in lung cancer,the area under the curve of adenocarcinoma union RDW,ALP,and non-surgical treatment was the largest,which was about 0.783;(5)Five independent risk factors predict bone metastasis in lung cancer,the area under the curve was about 0.780.Conclusion:1.RDW≥14.55%,PLT≥256.50×109/L,LP(a)≥287.00mg/L,adenocarcinoma,and non-surgical treatment were independent risk factors for bone metastasis in patients with lung cancer.2.The results of ROC curve analysis showed that The AUC was greater than 0.5for the five independent risk factors alone diagnosis,It was of certain value for predicting the occurrence of bone metastasis in lung cancer.and the accuracy ofmultiple risk factors combined predict was higher.