| At present,the contrast agents for the cancer diagnosis and the medicine to cure disease are usually separated in clinical.We would not have the chance for real-time monitoring the progress in the process of the disease treatment.Thus,we could not formulate a specific treatment strategy for each patient.As their inherent attributes of imaging technology contrast agents,they usually were made of heavy metal,heavy metal oxide or their complexes.The heavy metal element existing in the drugs,was easily enriched in organisms and did harm to them.And some elements even have radioactivity,which would produce side effects of treatment for patients.Surgical treatment,chemical treatment and radiation treatment are the three major traditional clinical treatment methods and easily accepted by patients for their certain development history.But,these three methods all have their inherent defects,bringing great side effects to the patients in the course of treatment,which contrary to the psychological needs of modern people to pursue a higher quality of life.Therefore,developing novel theranostic agents became a urgent demand for tumor treatment.In recent years,as the development and application of nanomaterials,researchers gradually focused their attentions on a new nanostructure drug.The new drugs will make the biological imaging and drug treatment together to realize the visualization of cancer treatment process,and decrease the side effects.Magneto-plasmonic nanoparticles have exhibited great potential in cancer diagnosis and therapy because of their excellent magnetism and optically activable plasmonic properties.However,it is still a great challenge to combine these two components on one single-nanoparticle.In this work,we developed two facile methods to synthesize monodispersed and uniform theranostic agents of nanoparticles.They have been demonstrated to be with excellent magnetic resonance(MR)and computed tomography(CT)imaging contrast abilities at different concentrations,and photothermal therapy ability.First one,the as-synthesized Fe3O4@SiO2@GNSs-PEG(PMGNSs)nanoparticles composed of a superparamagnetic Fe3O4 inner core,silica as the middlayer and coated with gold nanoshells at the outside,with uniform size distribution of less than 100 nm.They have been demonstrated to be with excellent magnetic resonance(MR)and computed tomography(CT)imaging contrast abilities at different concentrations.Meanwhile,the as-synthesized PMGNSs exhibited high stability with no significant change of photothermal performance after five laser ON/OFF cycles,and high photothermal conversion ability with temperature increase of 40 ? under 808 nm laser irradiation at 2 W·cm-2 for 10 min at the concentration of 160 ?g ml-1.Furthermore,in vitro photothermal therapy ability has also been demonstrated on HePG2 cancer cells.Second one,as-prepared Fe3O4@ZrO2@PDA-FA nanoparticles composed of superparamagnetic Fe3O4 inner core,zirconium dioxide as the middlayer and coated with polydopamine at the outside.The superparamagnetic ferroferric oxide was used as a magnetic core for MR imaging.The zirconium dioxide was made for CT imaging as its strong absorption of X-ray,and polydopamine can be used for photothermal therapy as its absorption in visible to near infrared.These two kinds of core-shell type nano materials,all have good uniform morphology structure and monodispersity.As verified,they can be used as the contrast agents for magnetic resonance(MR)and computed tomography(CT)imaging,and the property of the absorption at the near infrared can be used for photothermal therapy.The nanostructure materials will promote the further development for the integration of cancer diagnosis and therapy. |
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