Clinical Reaserch Of Acupuncture Using Daoqi Manipulation And Different Therapy In Different Time On Tubal Infertility

Objective: To observe the synergistic effect of acupuncture using Daoqi manipulation and different therapy in different time on tubal infertility.Methods: Select 72 patients who meet the inclusion criteria,then put them into two g roups by randomized control,36 cases in acupuncture group and 36 cases in control g roup.Ultrasound Oxygen oviductography in the control group.Acupuncture group add ed Daoqi manipulation and different therapy in different time to treatment group,and the main acupuncture points of treatment group are SanYinJiao(double),ZiGong(dou ble),GuiLai(double)and ZhongJi.Abdominal acupuncture points adopt Daoqi manip ulation.During different periods of menstruation(follicular phase,ovulation phase,an d luteal phase),warm acupuncture,electroacupuncture,and warm-needle acupuncture are used,and 3 times a week.1 menstrual cycle is a course of treatment,then check th e curative effect after 3 courses.Observing indicators for IL-6、TNF-α、TCM clinical symptom、tubal adhesions、intrauterine pregnancy、safety(adverse reactions).The infertility in the "Standard of TCM Syndrome Diagnostic Efficacy" is the comprehensive evaluation criterion.Results:(1)Comparing comprehensive curative effect of both groups: After treatment,21 cases were cured(intrauterine pregnancy)in the acupuncture group,6 cases were markedly effective,4 cases were effective,5 cases were ineffective,and the total effective rate was 86.11%,10 cases were cured(intrauterine pregnancy)in the control group,7 cases were markedly effective,6 cases were effective,13 cases were ineffective,and the total effective rate was 63.89%,the comprehensive efficacy of the two groups was compared(P=0.035),the difference was statistically significant(P<0.05),indicating that the comprehensive efficacy of the acupuncture group was better than that of the control group.(2)The comparison of two groups of TCM syndrome scores:In the acupuncture group,the pre-treatment score was 20.42±2.61,and 19.89±2.08 in the control group,the pre-treatment score of the two groups was P=0.346,and there was no statistically significant difference in TCM symptom scores(P>0.05),indicating that they were comparable.The scores of the acupuncture group were(9.67±2.03)after treatment,and the scores of the control group(14.81±2.03)after treatment.The scores of TCM symptoms after treatment were statistically significant(P<0.001).The difference was statistically significant(P<0.05).The differences between the two groupps before and after the group were statistically significant(P<0.05),indicating that the acupuncture group was better than the control group in improving symptoms of TCM.(3)The comparison of TCM Syndromes efficacy evaluation between two groups:the total effective rate of post-treatment of acupuncture group and contrast group is 94.44% and 58.33% respectively.The non-parametric rank sum test,Z = 4.14,P <0.001,the difference was statistically significant,indicating that the acupuncture group had better therapeutic effects than the control group.(4)Comparison between two groups before treatment: IL-6(P=0.901),TNF-α(P=0.395),there was no significant difference and comparable.After treatment,the differences between the groups were statistically significant(P<0.001).After paired T test,before and after treatment with IL-6 in acupuncture group,T=16.01,P<0.001;After paired T test,before and after treatment with IL-6 in control group,T=10.75,P<0.001;After paired T test,before and after treatment with TNF-α in acupuncture group,T=17.23,P<0.001;After paired T test,before and after treatment with TNF-αin acupuncture group,T=3.86,P<0.001;The differences within the group were statistically significant.indicating that the acupuncture group was superior to the control group in reducing serum IL-6 and TNF-α concentrations.(5)Comparison of ultrasound crystal oxygen detection after treatment in two groups(effective cases):definition is effective from slow to fast.After chi-square test,tubal development(P=0.018),crystal oxygen outflow(P=0.014),post-pressurized crystalline oxygen outflow(P=0.011),and diffusion(P=0.017),the difference between the two groups was statistically significant(P<0.05),indicating that the acupuncture group was superior to the control group in improving the usual degree of fallopian tube.(6)The pregnancy rate of the two groups was compared:The acupuncture group included 19 cases of pregnancy and 17 cases of non-pregnancy.The pregnancy rate was 52.78%.The control group included 9 cases of pregnancy and 27 cases of non-pregnancy.The pregnancy rate was 25%.The pregnancy rate in the two groups(P=0.016)was statistically significant(P<0.05),indicating that the acupuncture group can significantly improve the pregnancy rate.Comparing the total pregnancy rate after 3 months of treatment in the two groups: The acupuncture group included 21 cases of pregnancy and 15 cases of non-pregnancy.The pregnancy rate was58.33%.The control group included 10 cases of pregnancy and 26 cases of non-pregnancy.The pregnancy rate was 27.78%.The pregnancy rate in the two groups(P=0.024)was statistically significant(P<0.05),indicating that the total pregnancy rate in the acupuncture group was better than that in the control group.(7)Comparison of adverse reactions after treatment in two groups:In the acupuncture group,there were 2 cases of abdominal pain,2 cases of dizziness,and 1case of nausea and nausea.In the control group,there were 12 cases of abdominal pain,9 cases of dizziness,and 8 cases of nausea and nausea.The difference between the two groups was statistically significant(P<0.05),indicating that the incidence of adverse reactions after acupuncture treatment was lower than that of the control group.(8)Safety observation: No serious adverse reactions and adverse events occurred in both groups.There were no abnormalities in blood,urine,stool,liver and kidney f unction before and after treatment in both groups.Some patients in the control group e xperienced different degrees of adverse reactions,such as small abdominal pain,naus ea,dizziness,headache,etc.These adverse reactions were considered related to the ad verse reactions caused by ultrasound oviductography.Conclusion: Using Daoqi manipulation and different therapy in different time on patients with tubal infertility after Ultrasound Oxygen Oviductography,it can improve the clinical symptoms of traditional Chinese medicine,improve the functional movement of the fallopian tubes,and increase the intrauterine pregnancy rate,indicating that the synergistic effect of acupuncture using Daoqi manipulation and different therapy in different time on tubal infertility.The mechanism of action may be related to acupuncture can reduce serum IL-6,TNF-α concentration and reduce the fallopian tube inflammation.