Endovascular Implantation Of Iodine-125 Seeds Strand And Portal Vein Stenting Followed By Transcatheter Arterial Chemoembolization Combined Therapy With Sorafenib For Hepatocellular Carcinoma With Main Portal Vein Tumor Thrombus

Objective:To compare the therapeutic effect of portal vein stenting and endovascular implantation of iodine-125 seeds strand followed by transcatheter arterial chemoembolization combined with or without sorafenib in patients for hepatocellular carcinoma?HCC?with main portal vein tumor thrombus?MPVTT?.Materials and method:Forty-three patients with HCC complicated by MPVTT who received portal vein stenting and endovascular implantation of iodine-125 seeds strand followed by transcatheter arterial chemoembolization combined without?group A,n=38?or with?group B,n=15?sorafenib in our hospital during Jan.2010 and Aug.2015 were analyzed retropectively.Overal survival,progress free survival and procedure-related adverse event were compared between the two groups.Result:The technical success rate was 100%for placement of ¹²⁵I seeds strand and stent in the obstructed main portal vein.No serious procedure-related adverse events occurred.Median survival time of group A and B were 12.1months and 14.8 months,respectively?X²=4.35,P=0.037?.Additionally,Median progress free survival time of group A and B were 2.8 months and 4.0months,respectively?X²=9.56,P=0.002?.Conclusions:Endovascular implantation of iodine-125 seeds strand and portal vein stenting followed by transcatheter arterial chemoembolization combined with sorafenib could improve the survival time,the progress free survival time of patients with HCC complicated by MPVTT.