The Relativity Study Between Bone Metabolism Markers And Percentage Of Body Fat In Children

Purpose:The purpose of this study is to investigate the relationship between percentage of body fat and level of vitamin D₃,osteocalcin,and c-telopeptide of type I collagen in obese children and to provide a basis for children to lose weight and reduce the incidence of bone metabolism diseases.Methods:This survey included 167 children,aged 6 to 18 years,who admitted to Children’s Health Section of Children’s Hospital of Hunan Province from July 2016 to February 2017.For all objects researced,We measure their height and weight.We also detecte triglyceride,total cholesterol,high-density lipoprotein,and low density lipoprotein,and use enzyme-linked immunosorbent method（ELISA）to detect the lever of serum 25-hydroxyvitamin D₃（25-（OH）D₃）,use electrochemiluminescence to detect the lever of serum osteocalcin（OCN）,c-telopeptide of type I collagen（CTX）.And use body composition analyzer to determine the body fat and percentage of body fat（PBF）.We group all the research objects according to the standard of overweight and obesity judged by percentage of body fat（normal percentage of body fat group,slightly increased percentage of body fat group,moderate-severely percentage of body fat group）,then compare the level of blood lipid,serum 25-（OH）D₃,osteocalcin and c-telopeptide of type I collagen of each groups.And do the correlation analyses between percentage of body fat and serum 25-（OH）D₃,osteocalcin and c-telopeptide of type I collagen.Result:1.Compared to children with normal percentage of body fat,the level of low density lipoprotein of children with increased percentage of body fat is higher,but high-density lipoprotein is lower（P<0.05）.The level of triglyceride and total cholesterol have no significant differences between normal percentage of body fat group and slightly increased percentage of body fat group（P>0.05）.2.Compared to children with normal percentage of body fat,the level of OCN of children with increased percentage of body fat was obviously lower,but the level of CTX is higher（P<0.05）.3.The incidence of vitamin D deficiency in children with increased percentage of body fat was obviously higher than that of children with normal percentage of body fat（P<0.05）.4.The percentage of body fat and level of serum 25-（OH）D₃ and OCN were negatively correlated in children（P<0.05）,The percentage of body fat and level of CTX were positively correlated in children with increased percentage of body fat（P<0.01）.Conclusion:Children with increased Percentage of body fat are more likely to have vitamin D deficiency,lower lever of osteocalcin and higher lever of CTX,that is to say,fat will increase the incidence of bone metabolic abnormalities.