Academic Research Of Professor Mao Dexi In Treating Constipation Based On Data Mining Technology

Objective: Put the Traditional Chinese Medicine Inheritance Support system(V2.0.1)as the development platform,utilize data mining technology,use association rules,adopt data analysis and prescription analysis,carry on analysis of four properties,five tastes and channel tropism,analysis of medication frequency,analysis of associated prescription rules,analysis of new prescription and analysis of commonly used drugs;found the status of Professor Mao Dexi's academic thought about the treatment of constipation disease.So that the old traditional Chinese medicine can be more completely arranged and inheritted to achieve rapid,extensive and effective dissemination of academic thought.Methods: Extract effective prescription from cases and data of constipation patients who Professor Mao Dexi has treated since 2008-2017 in Henan Province Hospital of TCM(the Second Affiliated Hospital of Henan University of Chinese Medicine).Then entry these prescription into TCMISS(V2.0.1),and adopt analysis methods integrated by the system software,such as association rules analysis,entropy clustering,improved mutual information method,hierarchical clustering analysis and so on,to mini data in order to obtain Professor Mao Dexi's medication regularity and academic thought about treatment of constipation.Results: 107 cases,271 prescriptions,196 kinds of drugs were collected,Frequency analysis results show:1.Top 20 drugs of all commonly used drugs according to the use frequency from high to low ranking,namely:Atractylodis macrocephalae rhizoma?Glycyrrhizae aadix et rhizoma(Professor Mao Dexi likes to use Glycyrrhizae aadix et rhizom,so the Glycyrrhizae aadix et rhizom is included out-of-order to collect data more objectively)? Cannabis fructus ? Cassiae semen ? Pruni semen ? Hordei fructus germinatus?Apecae pericarpium?Setariae fructus germinatus?Ophiopogonis radix ?Dendrobii caulis?Armeniacae semen amarum?Arecae semen?Raphani semen?Coptis rhizoma ? Canavaliae semen ? Scrophulariae radix ? Oryzae fructus germinatus ?Pharbitidis semen ? Euodia rutaecarpa ? Rehmanniae radix ? Pinelliae rhizoma praeparatum cum alumine.2.10 commonly used combinations of drugs(removal of a core containing licorice):(1)Atractylodis macrocephalae rhizomaa?Cannabis fructus;(2)Atractylodis macrocephalae rhizoma?Cassiae semen;(3)Cannabis fructus?Cassiae semen;(4)Atractylodis macrocephalae rhizoma?Pruni semen;(5)Cannabis fructus?Pruni semen;(6)Atractylodis macrocephalae rhizoma?Hordei fructus germinatus;(7)Atractylodis macrocephalae rhizoma ? Apecae pericarpium;(8)Atractylodis macrocephalae rhizoma?Ophiopogonis radix;(9)Cassiae semen?Pruni semen;(10)Atractylodis macrocephalae rhizoma?Setariae fructus germinatus.3.Three medications combinations:(1)Atractylodis macrocephalae rhizoma ?Cannabis fructus?Cassiae semen;(2)Atractylodis macrocephalae rhizoma?Cannabis fructus?Pruni semen;(3)Atractylodis macrocephalae rhizoma?Cassiae semen?Pruni semen;(4)Cannabis fructus?Cassiae semen?Pruni semen.4.New prescriptions combinations:(1)Saposhnikoviae radix?Acori tatarinowii rhizoma?Fructus alpiniae oxyphyllae?Schizonepetae cpica;(2)Paeoniae radix alba praeparata cum melle?Viticis fructus?Cinnamomi ramulus?Linderae radix?Chuanxiong rhizoma?Retinervus Citri Fructus;(3)Forsythiae fructus?Lonicerae japonicae plos?Leonuri herba?Cyperi rhizoma;(4)Setariae fructus germinatus?Cassiae semen?Hordei fructus germinatus?Euodia rutaecarpa?Coptis rhizoma;(5)Glehniae radix?Fructus tritici levis?Stemonae radix?Adenophorae radix;(6)Aurantii fructus?Bupleuri radix?Dioscoreae rhizoma?Stellariae radix;(7)Chrysanthemi flos?Leonuri fructus?Gastrodiae rhizoma?Gypsum fibrosum;(8)scutellariae radix?Ephedrae herba?Lilii bulbus?Platycodonis radix?Stemonae radix;(9)Amomi fructus rotundus?Agastache rugosa ? Amomi fructus ? Galli gigerii endothelium corneum;(10)Trichosanthis pericarpium?Belamcandae rhizoma?Mori cortex?Phragmitis rhizoma?Polygonati odorati rhizoma ? Arctii fructu;(11)Phellodendri chinensis cortex ?Anemarrhenae rhizoma?Alismatis rhizoma?Rehmanniae radix?Gypsum fibrosum;(12)Cassiae seme?Hordei fructus germinatus?Pinelliae rhizoma praeparatum cum alumine?Coptis rhizoma;(13)Coptis rhizoma?Pruni semen?Cannabis fructus?Platycladi eemen.5.Traditional Chinese medicine usage statistics about frequency of use in the top ten:Atractylodis macrocephalae rhizoma 30g;Glycyrrhizae aadix et rhizoma 10g;Cannabis fructus 15g;Cassiae semen 30g;Pruni semen 10g;Hordei fructus germinatus15g;Apecae pericarpium 10g;Setariae fructus germinatus 15g;Ophiopogonis radix30g;Dendrobii caulis 20 g.Conclusion:1.The majority of constipation patients in section for outpatients are women.2.When Professor Mao Dexi treats constipation,Gan Wen Ping,into the spleen and stomach are mainly,nourishing yin for moistening dryness,strengthen spleen to promote digestion,promoting qi circulation and relieving depression and other drugs;drugs commonly used in Atractylodis macrocephalae rhizoma ? Cannabis fructus ?Cassiae semen?Pruni semen?Hordei fructus germinatus?Apecae pericarpium?Setariae fructus germinatus ? Ophiopogonis radix ? Dendrobii caulis ? Armeniacae semen amarum?Arecae semen.3.Professor Mao Dexi is goot at large doses of Atractylodis macrocephalae rhizoma to treat constipation.The commonly used dosage is 30 g,the maximum is from 60 g to90g,and Professor Mao Dexi may increase and decrease the dosage based on the severity of constipation.4.The combination of data mining technology of TCMISS and manual collection of data is beneficial to the clinical experience of Chinese famous traditional medicine doctors of famous and traditional Chinese medicine,provides an important basis for clinical research,and can promote the spread of academic thought of doctors of famous and traditional Chinese medicine.Meanwhile,it will be helpful to find out the value and efficacy of the new prescription,which need to be further verified in the future clinical work.