Clinical Data Analysis Of Acute Kidney Injury Induced By Acute Organophosphate Poisoning

BackgroundOrganophosphate pesticides are widely used in China and some developed countries in the world.As cheap and powerful insecticides,they have little damage to crops and have good effects^[1].With the wide application of organophosphate pesticides in agriculture,the damage to mammals caused by it has gradually attracted people's attention.Organophosphate pesticides have a strong acute toxicity,and may cause damage to the human lungs,heart,brain,kidneys,and other organs,and even cause disability and death.In the past,there were many studies on lung,liver and heart toxicity caused by organophosphate pesticides,and there were rarely reported on acute kidney injury?AKI?caused by organophosphate pesticides.There are few studies on the pathogenesis and risk factors of acute renal injury induced by organophosphate poisoning,and the number of cases in the previous studies is generally low,and the case report is common.ObjectiveTo observe the clinical characteristics of AKI caused by acute organophosphate pesticide poisoning,and analyze the risk factors of AKI caused by acute organophosphate pesticide poisoning,and give early intervention to improve the prognosis of patients.MethodsWe retrospectively analyzed the laboratory findings of 286 patients with acute organophosphate poisoning admitted to the Central Hospital of the Chinese People's Liberation Army from January 2009 to June 2016.The main research:?1?286 cases of with acute organophosphate poisoning patients were grouped according to the presence of AKI.We want to observe whether the clinical indicators were statistically different in the two groups.?2?Firstly,single factor analysis was used to compare the differences between the two groups.After the single factor analysis,there were statistically significant differences.Logistic regression was used to analyze the risk factors affecting acute kidney injury.ResultsAmong the 286 patients with acute organophosphate pesticide poisoning,95?33.2%?cases showed AKI,and the cure of AKI group was 56.8%?54/95?,and the mortality rate was 9.5%?9/95?.The cure rate of no AKI group was 73.3%?140/191?,and the mortality rate was 2.1%?4/191?.Patients with two groups of general data and clinical characteristics,gender has no statistical significance?P=0.219?,and patients with poisoning time,amount of poison,blood c-reactive protein and serum creatinine comparing respectively in the two groups have statistical significance?P<0.001?,peripheral blood leukocytes have statistical significance?P=0.030?.Multivariate logistic regression analysis showed that the patients had a statistically significant difference in the length of time of poisoning,large dose of drug,increased c-reactive protein in peripheral blood,and elevated serum creatinine?P<0.05?.There was no statistical significance in peripheral blood leukocyte in patients?P>0.05?.Conclusions1.Acute organophosphate pesticide poisoning leads to a relatively poor prognosis of acute kidney injury;2.The risk factors affecting AKI of acute organophosphate pesticide poisoning may be related to long time of poisoning,large dose of dose,high c-reactive protein,and elevated serum creatinine.