A Clinical Study On The Correlation Between Female Infants With Prematurp Thelarche And Environmental Endocrine Disruptors

Objective:A clinical study on the correlation between female infants with premature thelarche and environmental endocrine disruptors bisphenol A,diethyl phthalate,4-nitrophenol,diethylhexyl phthalate.Method:Using case-control study method,collecting 80 female infants with premature thelarche?IPT group?were diagnosed in the endocrinology department of Children's Hospital in Jiangxi Province,from October 2015 to February 2016,and collecting healthy non-breast development female infants 30 cases?the control group?.All cases were accepted the questionnaire survey,sex hormones test,uterus and breast ultrasonic testing.Then to measure all cases serum bisphenol A,diethyl phthalate,4-nitrophenol,diethylhexyl phthalate level with the method of high performance liquid chromatography.Finally,use the method of t-test and Pearson-test to analyze the correlation between serum BPA,DEP,4-NP,DEHP content and clinical parameter.Result:After one year following-up,the IPT group included 62 cases with the mean age of 32.35±3.38 months and all older than two years,then divide them into the faded-away group and non faded-away-group on the basis of whether the breast faded away.The faded–away group included 33 cases with the mean age of 31.45±3.30months and the fading rate was 53.2%and the non-faded–away group included 29cases,there was only one case was diagnosed with idiopathic central precocious puberty.Results of t-test:there were significant differences between the IPT group and the control group in serum level of BPA,DEP,4-NP,DEHP,E²?p<0.05?.While there were no significant differences between the IPT group and the control group in the age,the basal level of serum LH and FSH,the uterine volume?P>0.05?.There were significant differences between the breast faded-away group and the non-faded-away group in the basal level of serum LH and E²,the breast volume?p<0.05?.While there were no significant differences between the breast faded-away group and the non-faded-away group in the basal level of serum FSH,the uterine volume?P>0.05?,the serum level of BPA,DEP,4-NP,DEHP?P>0.05?.Results of Pearson-test:In the IPT group,while there were no significant correlation between the serum level of BPA,DEP,4-NP,DEHP and the basal level of serum LH,FSH,E²?P>0.05?.There were no significant correlation between the serum level of BPA,DEP,4-NP,DEHP and the age,uterine volume,breast volume either.?P>0.05?.Conclusion:Female infants from one month to two years old with premature thelarche have higher serum BPA,DEP,4-NP,DEHP content and E₂ level than the healthy infants,and the occurrence of premature thelarche may relate to serum BPA,DEP,4-NP,DEHP content E₂ level.For female infants more than two years old,the breast do not fade away may relate to the higher basic serum level of LH,E₂ and breast volume.While whether the breast fade away may be not related to serum BPA,DEP,4-NP,DEHP content.The serum level of EEDs and estrogen may be two independent risk factors related to female infants from one month to two years old with premature thelarche.