| Objective:The purpose of this study was to analyze the prenatal diagnosis of different types and quantities,and to explore the relationship between single or joint indications and fetal chromosomal abnormalities.Methods:A retrospective analysis was conducted of 4,323 cases of prenatal diagnosis of para-amniocentesis in the prenatal diagnosis center of ningxia medical university general hospital from January 2012 to November 2017.Fetal chromosomal abnormalities include structural abnormalities,abnormal numbers and polymorphism.Into the indications of 7:serologic screening high-risk(A),in advanced maternal age(B),abnormal ultrasonic fingdings(C),the histories of abnormal pregnacy(D),the histories of poor contact(E),couples chromosome abnormality(F),NIPT anomalies(G).The seven prenatal diagnostic indications were divided into three groups: the single term group,the combined two indications group,the combined three or more indications group.Statistical methods were used to analyze the correlation between all prenatal diagnostic indications and chromosomal abnormalities.Results:Among the 4323 samples of amniotic fluid,2 of them failed to develop,the success rate was 99.95%,588 cases were detected with chromosome abnormality,and the detection rate was 13.60%,including 323 cases of chromosome polymorphism,and the detection rate was 7.47%;120 cases of structural abnormalitiesand,the detection rate was2.78%;145 cases of abnormal numbers,and the detection rate was 3.35%.(1)in single indications,group F fetal chromosomal anomaly detection rate(9/16),the highest compared with other single indications,with significant difference statistically significant,the rest of the individual indications of two contrast,the difference was not statistically significant.(2)in thecombination of two indications,the highest detection rate of chromosomal abnormalities was C+G(63.64%),followed by A+G(60.00%)and B+G(57.14%).C+G was compared with A+B,A+F,A+G,B+F,and B+G,and the difference was not statistically significant.The comparison with the other 13 groups was P < 0.01,with significant difference and statistical significance.A+G was compared with A+C,A+D,B+D,C+D,C+E,and the differences were statistically significant.Compared with other groups,the difference was not statistically significant.B+G was compared with A+C,A+D,B+C,B+D,B+E,C+D,C+E,the difference was statistically significant,and the difference was not statistically significant compared with other groups.(3)combination of three or more indications set of pairwise comparison,differences were not statistically significant,B+C+D group compared with the corresponding single group,with significant difference statistically significant,compared with B+D,the difference was statistically significant.(4)The abnormal detection rate of fetal chromosome number between in the group of 35 to 39 years old and the groups of 40 years and older were compared,andthe difference was statistically significant.(5)Compared with the abnormal chromosome detection rate between abnormal ultrasound results and normal ultrasound results,and the difference was statistically significant.(6)The sensitivity of chromosome aneuploidy in 21,18 and 13 was 100.00% by noninvasive prenatal testing.The sensitivity of chromosome aneuploidy in 21,18 and 13 was 100.00% by noninvasive prenatal testing.The specificityare respectively93.62%,and 96.55%,and 95.00%,and 83.33%.Conclusion:(1)There is a correlation between the number of prenatal diagnostic indications and fetal chromosomal abnormalities.(2)The correlation with fetal chromosomal abnormalities was highest in those with conjugal chromosomal abnormalities in the single index and in those with ultrasonic abnormalities combined with NIPT abnormalities in the combined two indices.(3)Pregnant women over 40 have an increased risk of abnormal chromosome Numbers in their fetuses.(4)The risk of abnormal chromosomes increases in fetuses with ultrasound abnormality and high risk of NIPT. |
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