The Correlation Between Total Serum IgE And Pulmonary Function In Asthma-Chronic Obstructive Pulmonary Disease Overlap Patients In Plateau Area

Objective:The purpose of this study was to mensurate the changes of total serum IgE and pulmonary function in patients with asthma-chronic obstructive pulmonary disease overlap at high altitude and to determine whether there is any correlation between them.To explore the significance and value of total serum IgE in the diagnosis and assessment of ACO.Methods:We recruited patients with acute exacerbation of asthma,chronic obstructive pulmonary disease or ACO hospitalized in Department of Respiratory Medicine,Affiliated Hospital of Qinghai University from December 2016 to December 2017 in the plateau area?elevation is more than 2500m?.A total of 90 cases,30 patients were randomly selected in asthma group,COPD and ACO group,respectively.To collect clinical data from these subjects,including age,sex,smoking index,arterial blood gas analysis,total serum IgE,lung function and peripheral blood eosinophil count.We analysed the relationship between total serum IgE and lung function related indicators comprehensively.Results:1.Total serum IgE level in ACO group was 400.16±85.76?ng/mL?,which was significantly higher than in COPD group?P<0.05?.Total serum IgE was significantly higher in asthmatic group than in COPD group?P<0.05?.Total serum IgE had no significant difference between ACO group and asthma group?P>0.05?.2.To compare lung function indexes among asthma group,COPD group and ACO group patients.Pulmonary function indexes?FEV₁%Pred,FVC%Pred,FEV₁/FVC%,PEF%Pred,MMEF%Pred?in asthma group were significantly higher than those in ACO group?P<0.05?.The lung function indexes?FEV₁%Pred,FVC%Pred,FEV₁/FVC%,PEF%Pred,MMEF%Pred?in asthma group were significantly higher than those in COPD group.There was no statistical difference between COPD group and ACO group in pulmonary function indexes?P>0.05?.3.The total serum IgE in ACO group was negatively correlated with FEV₁%Pred and FEV₁/FVC%?P<0.01?.No correlation was found in total serum IgE with other pulmonary function parameters(FVC%Pred,PEF%Pred,MMEF%Pred,RV/TLC%P>0.05.4.ACO group,COPD group and asthma group have no significant difference in peripheral blood eosinophil count?P>0.05?.Conclusion:1.The level of total serum IgE in patients with ACO was negatively correlated with FEV₁%Pred and FEV₁/FVC%,suggesting that total serum IgE level could be used as an effective index to assess the degree of airflow limitation.The higher the level of total serum IgE,the heavier the impairment of lung function.2.Peripheral blood eosinophil count couldn't be used in differential diagnosis and estimating the severity of ACO group,COPD group and asthma group.