A Multimodal Research Of MRI On Healthy Adults’ Intelligence

ObjectiveIn the study,we explored the neurobiological underpinnings of individual differences in intelligence by using voxel-based morphometry,regional homogeneity,functional connectivity in a large sample of healthy adults.The method of MRI included the brain structure and function,as well as the regional and whole brain.It is useful for us to understand the neurobasis of intelligence fully.On the other hand,it contributes to us to develop more reliable assessment tools about intelligence based on the cognitive neuroscience.Methods(1)The current study included 208 right-handed healthy volunteers who were conform to the recruitment standards.Guided by instructions from a professional experimenter,the participants finished the Chinese Revised Wechsler Adult Intelligence Scale(WAIS-RC)and were acquired the imaging data.(2)Based on R2014 a MATLAB platform,we used SPM12,SPM8,VBM8,DPARSF、Rest、Xjview、Brain Net、SPSS17 software to calculate the VBM,Re Ho,FC,and then carried out statistical analysis.Results(1)Relationship between full-scale intelligence quotient(FSIQ)and VBM,Re Ho,FCPositive correlations between the VBM results and the FSIQ scores were observed in the right calcarine fissure and surrounding cortex and negative correlations occurred in the right dorsolateral superior frontal gyrus and bilateral middle temporal gyrus.Positive correlations between the Re Ho results and the FSIQ scores were observed in the right medial superior frontal gyrus and no negative correlation results.Positive correlations between the FC results and the FSIQ scores were observed in the right supramarginal and angular gyri of inferior parietal,bilateral inferior frontal gyrus,left anterior cingulate gyri,medial superior frontal gyrus and no negative correlation results.(2)Relationship between performance intelligence quotient(PIQ)and VBM,Re Ho,FCPositive correlations between the VBM results and the PIQ scores were observed in the left calcarine fissure and surrounding cortex and negative correlations occurred in the left anterior cingulate gyri and left middle temporal gyrus.Positive correlations between the Re Ho results and the PIQ scores were observed in the right rolandic operculum,right dorsolateral superior frontal gyrus and negative correlations occurred in inferior occipital gyrus.Positive correlations between the FC results and the PIQ scores were observed in the right middle frontal gyrus,right supramarginal and angular gyri of inferior parietal and no negative correlation results.(3)Relationship between verbal intelligence quotient(VIQ)and VBM,Re Ho,FCNegative correlations between the VBM results and the VIQ scores were observed in the left hippocampus and no positive correlation results.The VIQ scores were not found to correlate significantly with the Re Ho of any brain region.Positive correlations between the FC results and the PIQ scores were observed in the pars opercularis of the right inferior frontal gyrus,the pars triangular of the left inferior frontal gyrus,right supramarginal and angular gyri of inferior parietal and no negative correlation results.ConclusionsIn conclusion,we explored the neural basis of intelligence using VBM,Re Ho,FC.The results showed that the neural basis of intelligence mainly occurred in the frontal lobe and parietal lobe,which supported the existing P-FIT theory further.