Preparation And Application Of Graphene-supported Copper Nanoparticle Catalysts

Graphene was widely concerned due to its strong specific surface area,conductivity and thermal stability.one of the research hotspots is that graphene supported copper nanoparticles as an efficient catalyst are used in organic synthesis.In this paper,Cu/graphene and Cu-Cu2O/graphene were designed and synthesized by one-pot reduction method,and their structures were characterized.The catalysts were applied to Ullmarnn reaction and "click" reaction respectively.Thus the new system of the two green catalytic synthesis reactions were developed.Firstly,Cu/graphene catalyst was applied to Ullmann reaction,and a new system of Cu/graphene-catalyzed Ullmann reaction in ionic liquid as solvent was developed by investigating reaction conditions including solvents,catalyst,temperature and so on.11 Symmetric biaryl compounds were successfully synthesized through this new catalytic system.The catalytic system not only can catalyze homocoupling reaction of halogenated aromatics effectively,but also have a good effect on homocoupling reaction of arylboronic acids.At the same time,Cu/graphene could be recycled 5 times without loss of activity.Secondly,Cu-Cu2O/graphene catalyst was applied to "click" reaction,and a new system of "click" reaction in the ethanol/water as solvent was developed by optimizing reaction conditions including the solvent,catalyst,temperature and so on.321,2,3-Triazole compounds were synthesized by the catalytic system.In these compounds,five target compounds were new structures and the other two were linezolid derivatives.The catalytic system not only can catalyze the "click" reaction of halides,but also have a good effect on the ''click'' reaction of mesylates or arenediazonium salts.Moreover,Cu-Ciu2O/graphene could be recycled 4 times without loss of activity.