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Polycaprolactone@polypyrrole Nanofiber Membrane Sensor Based On Graphene And Metal Nanoparticles And Its Application

Posted on:2018-11-06Degree:MasterType:Thesis
Country:ChinaCandidate:Z Z WangFull Text:PDF
GTID:2351330515980572Subject:Analytical Chemistry
Abstract/Summary:PDF Full Text Request
In this study,nanofiber is of interest because of its wire-like material with a diameter of nanoscale and long length and its potential to be used in micro wires,micro fiber materials,novel laser materials,and light-emitting diodes materials as well as the sensing materials.While in this specific study,electrospinning has been employed to fabricate the nanofibers due to its relatively simple and cost-effective production method as well as its capability to prepare the materials with high porosity and high specific surface area.Polypyrrole is a kind of important heterocyclic conjugated conducting polymers,which has the characteristics of high conductivity,redox properties,electronic transport capability and excellent stability.By combining conductive nanofiber membrane and polypyrrole together,the conductive nanofiber membrane with the spatial reticulated structure can be prepared.Graphene is the carbon materials with the unique two-dimensional structure of a single layer or multi-layers,which has attracted people's attention for its good electrical conductivity,thermal conductivity,large specific surface area.Metal nanomaterials refers to the metal materials in nanometer scale with at least one dimension in three-dimensional space or by them as the basic units.The metal nanomaterials hold more unique properties by comparing with nanometer materials,such as higher catalytic activity and excellent electrical conductivity,by combining its chemical and physical properties with special properties of nanomaterials.The interesting hypothesis if the high performance electrochemical sensors can be prepared by decorating metal nanoparticles onto the surface of RGO and the substrate of nanofiber membranes.To date,drug monitoring and environmental pollution with the application of electrochemical sensor are getting more and more attention.Dopamine(DA)as an important neurotransmitter plays a key role in the function of the central nervous,renal and hormonal system.It is a common pharmaceutical compound for treating central nervous system disorders,such as schizophrenia and Parkinson's disease.It is clear to people that excessive or deficient drugs could not work effectively in the pathology treatment.The detection and amount control of dopamine becomes the very important topic in clinical diagnosis.Rifampicin is a semisynthetic antibiotic from rifamycin B,which can inhibit the DNA of bacterial transcribing RNA.It can be used in the treatment of tuberculosis(TB),enterococcus infection,etc.Nitroaromatic compounds are used in the manufacturing of dyes,plasticizers,pesticides,fungicides and explosives.The harmful effects of p-NP on humans include headache,fever,breathing trouble and even death at high levels of exposure,which again requires the better control and quantity monitoring.According to the discussion above,this work has been designed to perform the electrochemical catalysis,testing and practical application on dopamine(DA),rifampin(RIF)and nitro phenol(p-NP)with the electrochemical sensors fabricated by metal nanoparticles,graphene and conductive nano-fiber materials.This thesis consists of the following three aspects:(1)By combining the electrostatic spinning technology and the electrochemical methods,RGO/PDDA/PCL@PPy materials with three-dimensional structure was able to capture and stretch graphene continuously.The nanometer fiber membrane shows good flexibility and can product quickly.The novel sensor contributes the excellent electrocatalytic activity toward DA with the detection limit of 0.34 ?M and high reproducibility as well as the reasonable stability,and the current responses are proportional to the concentrations from 4 to 320 ?M.It should be noted that such DA sensor could be fabricated in a massive way.The proposed electrochemical sensor has shown the promising potential to perform on-field measurement of DA in clinic and drug diagnosis.(2)AuNPs/RGO/PCL@PPy nanofiber membranes was fabricated by the electrostatic spinning and the electrodeposition method,which has combined the properties of good electrical conductivity of graphene and the excellent electric catalytic characteristics of gold nanoparticles.This nanofiber membranes possessed the three-dimensional structure hold the excellent electrocatalytic activity toward the reaction of p-NP with a detection limit of 20 nM based on S/N=3.The current responses are proportional to the concentrations from 80 nM to 800 ?M.p-NP can be directly detected in the presence of o-NP attributing to the capable separation of p-NP and o-NP peaks within the scanning potential.(3)NixOy/RGO/PCL@PPy nanofiber membranes was fabricated by the electrostatic spinning and the electrodeposition method.This nanofiber membranes show excellent electrocatalytic activity toward RIF with a detection limit of 0.2 ?M based on S/N=3 and are proportional to the concentrations from 2 to 370 ?M.The electrode has proved the promising potential to perform on-field measurement of Rif in Rifampicin Eye Drops.
Keywords/Search Tags:nanofibers, electrostatic spinning, polypyrrole, graphene, metal nanoparticles, sensors
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