A New Method Based On The Formation Of CH Bond Functionalized Carbon Hetero Bonds

The C-H bond functionalisation dramatically streamline multi-step chemical processes.This method has caused extenisve attentions in recent 'years.In this dissertation,the C-O bond?C-N bond?C-S bond?C-Se bond and C-X(X=CI,Br,I)bond are able to be conducted directlly from C-H bond functionalisation.1.A palladium-catalyzed ortho-halogenation(I,Br,Cl)of arylnitrile is described.The optimal reaction conditions were identified after examining various factors such as catalyst,additive,solvent,and reaction temperature.Using cyano as the directing group,the halogenation reaction gave good to excellent yields.2.The oxidative coupling of methylarenes and N,N-dialkylformamides was developed,and the appropriate reaction conditions were established.By using I2 as the catalyst,and TBHP as the oxidant,the reaction provided N,N-dialkylamides or N-alkylamideswith moderate yields via multiple sp C-H bonds activation of methylarenes in aqueous and metal-free conditions.3.The nBu44NI-catalyzed sequential C-O and C-N bond formation via multiple sp3C-H bonds activation of ethylarenes,using N,N-dialkylformamide as the amino source,provided a-ketoamides with moderate yields.4.The syntheses of sulfides and selenides through the direct aliphatic C-H bond functionalization.