Analysis Of Arsenic, Cadmium And Lead In Marine Products In Shenzhen And Oral Bioavailability Of Arsenic, Cadmium And Lead In Oysters

With the rapid development of society and economy,the increasing emission of toxic elements As?Cd and Pb has been a threat to the safety of seafood.Seafood is one of people's favorite foods.However,total heavy metal concentration in seafood does not represent the actual degree of toxic metal ingestion by humans,because toxic metals can be excreted through the feces and urine.Therefore,understanding bioavailability of toxic metal concentrations in food is capable to estimate amount enables the estimation of the amounts of toxic metals that can be absorbed by the human body.We randomly selected 462 seafood as research object from three county's agricultural products markets in Shenzhen.Seafood mainly included pelagic fish,benthic fish and bivalves.Pelagic fish include Pampus punctatissimus and Perca fluviatilis,benthic fish include Lutjanus erythropterus and Paralichthys olivaceus,bivalves include Argopecten irradias,Crassostrea rivularis,Meretrix meretrix,Panopea abrupta,Paphia undulate.The edible parts of samples were digested in a Microwave Digestion System and analyses were conducted using ICP-MS.Furthermore,the bioavailability of As,Cd,and lead(Pb)in mice after 20-day oral ingestion of Crassostrea rivularis was investigated,and the total rate of absorption of toxic elements in samples from liver and kidney tissues and blood were determined.Results:1.The average rates over standard are Arsenic 37.2%(172/462),Cadmium 11.7%(54/462),Lead 0(0/462)respectively.2.Analysis of the Arsenic,Cadmium and Lead in different types of seafood.(1)Arsenic concentration: pelagic fish< benthic fish(P<0.01),pelagic fish<bivalves(P<0.05).As concentration in benthic fish and in bivalves are not significantly different(P>0.05),but As concentration in bivalves was higher than in pelagic fish(P<0.01).(2)Cadmium concentration: fish<bivalves(P<0.01).(3)Lead concentration: fish<bivalves(P<0.01)?3.Our used to target hazard quotients(THQs)to assess the potential health riskof the seafood samples,the value of THQs and total THQs were less 1.Implying the low health risk associated with individual element exposure.4.The total rate of absorption of toxic elements in samples from liver and kidney tissues and blood were determined,the oral bioavailability of As,Cd,and Pb was approximately 0.33%,0.45%,and 0.74%,respectively.In addition,our findings evidenced that the As concentration in the kidneys and liver and the Cd concentration in the kidneys presented an obvious linear relationship with the amount of orally ingested oyster-based feed.